Macrocyclic compounds are an attractive class of therapeutic ligands against challenging targets, such as protein–protein interactions. However, the development macrocycles drugs is hindered by lack large combinatorial macrocyclic libraries, which cumbersome, expensive, and time consuming to make, screen, deconvolute. Here, we established a strategy for synthesizing screening libraries on picom...

The aim of the present study was to investigate the potential genes involved in drug resistance of Candida albicans (C. albicans) by performing microarray analysis. The gene expression profile of GSE65396 was downloaded from the Gene Expression Omnibus, including a control, 15‑min and 45‑min macrocyclic compound RF59‑treated group with three repeats for each. Following preprocessing using RAM, ...

An efficient chemoselective process for the synthesis of 14- and 15-membered triazole-containing macrocycle compounds has been developed through the combination of two multicomponent reactions and an intramolecular Sonogashira cross-coupling reaction.

Two macrocyclic compounds with a rhomboid molecular shape, composed of a π-conjugated framework and an imine or amine functionality, were synthesized. The amine-containing macrocycle crystallizes with step-like interaction of each molecule, forming a columnar arrangement, although dispersion of the imine gelates upon ultrasonification.

The antimicrobial activity of methanol extracts three thalloid liverworts, Marchantia polymorpha, Conocephalum conicum and Pellia endiviifolia bis-bibenzyl marchantin A, the most dominant compound in extract M. have been investigated this research. 1H-NMR spectroscopy revealed that polymorpha P. liverwort contain terpenes, oils, sugars bis-bibenzyls, while these specific macrocyclic compounds w...

In this study, we examine macrocyclic compounds to determine whether they can provide a safer replacement and stable complex for BPA in thermochromic dyes. To achieve objective, series of compounds, Methyl-N-benzylhexahomotriazacalix[3]arene (MeAC3), p-Chloro-N-benzylhexahomo-triazacalix[3]arene (ClAC3), ?-Cyclodexdrin (?-CD), ?-Cyclodexdrin (?-CD), p-tert-Butylthiacalix[4]arene (TC4), Calix[4]...

Cyclodextrins (CDs) are well-known macrocyclic compounds in the fields of supramolecular and molecular recognition. For use as separation adsorption materials, water-soluble CDs must be modified into solid forms. Hybrid polymers consisting amorphous silica α- or β-CDs (propyl-modified α-CD, butyl-modified β-CD, ethylenediamine modified-βCD), designated propyl-α-CDP (2), butyl-β-CDP (3), EDA-β-C...