When Escherichia coli was treated with sarcotoxin I, a potent bactericidal protein of Sarcophaga peregrina (fleshfly), K+ inside of the cells leaked out rapidly and the ATP pool of the cells rapidly decreased. These results suggested that the bactericidal effect of sarcotoxin I was due to its ionophore activity, and that it blocked the generation of ATP by inhibiting formation of the proton gra...

We report on a chemical-sensing method based on the silica-micelle mesophase wherein both a fluoroionophore and a masking agent are embedded. Using this method, a highly selective detection of metal ions in an aqueous solution has been successfully demonstrated. Furthermore, simultaneous analyses of multisamples using a sensor array composed of functionalized mesoporous thin films were demonstr...

Key words rhodium catalysis - C–H functionalization macrocyclic peptides tryptophan-containing

Focusing on ionophore-based ion-selective electrodes (ISEs), this work highlights recent advances in increasing sensor sensitivity by converting potentiometric response to a variety of electrical and optical signals including charge, current, luminescence, color change.

background: globozoospermia is a rare (incidence of 0.1% among andrological patients) and poorly understood condition, but a severe disorder in male infertility. this case report detailed the course of treatment and protocol of a patient with type 1 globozoospermia using intracytoplasmic sperm injection (icsi) and oocyte activation by calcium ionophore, which yielded conception and birth of a h...

Compared to structurally related linear trialkylamines, a simple macrocyclic amine with an anion-binding cavity exhibits very large rate enhancements (>10(5)) for stoichiometric N-alkylation with primary alkyl, allyl, and benzyl halides in the weakly polar solvent CDCl3. There is also a major distortion of the halide leaving-group order. For example, with benzyl halides the relative leaving-gro...

Threading of a polymer through a macrocyclic ring may occur directly, that is, by finding the end of the polymer chain, or by a process in which the polymer chain first folds and then threads through the macrocyclic ring in a hairpin-like conformation. We present kinetic and thermodynamic studies on the threading of a macrocyclic porphyrin receptor (H2 1) onto molecular threads that are blocked...

Synthetic superoxide dismutase mimetics have emerged as a potential novel class of drugs for the treatment of oxidative stress related diseases. Among these agents, metal complexes with macrocyclic ligands constitute an important group. In this work we synthesized five macrocyclic copper(II) complexes and evaluated their ability to scavenge the superoxide anions generated by the xanthine-xanthi...

The membrane lipid of a new deep-sea hydrothermal vent methanogen, Methanococcus jannaschii, was isolated, purified, and structurally characterized. The total lipid extract, amounting to 32.2 micrograms/mg, dry cell weight, was fractionated on silica gel into a neutral lipid and polar lipid fraction. The neutral lipid fraction consisted of a series of isoprenoid hydrocarbons and free (nonphosph...

In this paper we report the synthesis and characterization of two new binuclear Cd(II) macrocyclic Schiff base complexes [CdL23pydfp(NO3)], (1), and [CdL33pydfp(NO3)], (2). [1+1] cyclocondensation of L23py = N-(2-pyridylmethyl)-N-(3-aminpropyl)-1,3-diaminoethane and L33py = N-(3-pyridylmethyl)-N-(3-aminpropyl)-1,3-diaminopropane and 2,6-diformyl-4-methylphenol, dfp, in the presence of Cd(NO3)2....