BACKGROUND This study examines the effect of low daily physical activity levels and overweight/obesity in pregnancy on delivery and perinatal outcomes. METHODS A prospective cohort study combining manually collected postnatal notes with anonymised data linkage. A total of 466 women sampled from the Growing Up in Wales: Environments for Healthy Living study. Women completed a questionnaire and...

Evidence suggests that the consequences of macrosomia on offspring’s health echoes well beyond neonatal period. In this study we have delineated potential association between diabetes mellitus during pregnancy - a major risk factor for macrosomia, and neurological morbidity. A population-based cohort was conducted, included consecutive deliveries macrosomic infants (birthweight above 4 kilogram...

BACKGROUND AND AIMS Infant and adult obesity is becoming a real public health concern in Romania, similar to other countries of the European Union. Maternal obesity and excessive weight gain during pregnancy are proven risk factors for the obesity of the child. The protective role of the breastfeeding against obesity has also been demonstrated. The most important issue is whether the choice of ...

BACKGROUND Mutations in ABCC8 and KCNJ11 are the most common cause of congenital hyperinsulinism (CHI). Recessive as well as dominant acting ABCC8/KCNJ11 mutations have been described. Diazoxide, which is the first line medication for CHI, is usually ineffective in recessive ABCC8 mutations. We describe the clinical and molecular characterisation of a recessive ABCC8 mutation in a CHI patient t...

BACKGROUND & OBJECTIVES To examine the effect of abnormal oral glucose loading (OGL) and number of abnormal oral glucose tolerance test (OGTT) values on foetal weight in Turkish pregnant women. METHODS This retrospective study included 810 pregnant women between 24 and 28 wk of gestation who were screened for gestational diabetes mellitus (GDM). Women were grouped according to degree of gluco...

Despite the well-known influence of maternal glucose on infant birth weight (BW), the prevalence of large for gestational age (LGA) infants ($90th percentile for age) has been increasing steadily over decades, particularly in pregnancies complicated by pregestational or gestational diabetes mellitus (1). Although the overall prevalence of macrosomia (BW$4,000 g) is 17–29% in women with untreate...