نتایج جستجو برای: maff
تعداد نتایج: 182 فیلتر نتایج به سال:
Biochemical analysis of megakaryocytes, the precursors of blood platelets, is limited by their rarity in vivo, and studies on lineage-specific gene expression have been conducted exclusively in cell lines with limited megakaryocytic potential. Mice lacking the transcription factor NF-E2 display arrested megakaryocyte differentiation and profound thrombocytopenia. To study the heterodimeric NF-E...
The pituitary hormone prolactin (PRL) plays an important role in mammary gland development. It was also suggested to contribute to breast cancer progression. In vivo data strongly supported a crucial role of PRL in promoting tumour growth; however, PRL demonstrated only a weak, if any, pro-proliferative effect on cancer cells in vitro. Several recent studies indicated that PRL action in vivo ma...
Transcription regulatory genes are crucial modulators of cell physiology and metabolism whose intracellular levels are tightly controlled to respond to extracellular stimuli. We studied transcription regulatory genes modulated by angiotensin II, one of the most important regulators of adrenal cortical cell function, and their role in adrenal steroidogenesis in H295R human adrenocortical cells. ...
The demand of exotic ions prior to their injection into an accelerator has driven the development of the charge breeding method. Existing facilities like REX-ISOLDE or ISAC at TRIUMF are already using a charge state booster for the post acceleration of radioactive ions. Planned facilities like MAFF, SPES, SPIRAL II and EURISOL have identified the need of a breeding system because of the demand ...
Classically or alternatively activated macrophages (M1 and M2, respectively) play distinct and important roles for microbiocidal activity, regulation of inflammation and tissue homeostasis. Despite this, their transcriptional regulatory dynamics are poorly understood. Using promoter-level expression profiling by non-biased deepCAGE we have studied the transcriptional dynamics of classically and...
Rhizobium BICC 651, a fast-growing strain isolated from root nodule of chickpea (Cicer arietinum L.), produced a catechol siderophore to acquire iron under iron poor condition. A Tn5-induced mutant (B153) of the strain, BICC 651 impaired in siderophore biosynthesis was isolated and characterized. The mutant failed to grow on medium supplemented with iron chelator and grew less efficiently in de...
The University of Hertfordshire, funded by MAFF and in collaboration with ADAS and IACRRothamsted, is currently developing a computer-based decision support system to encourage and enhance best practice within arable agriculture such that environmental protection can be given a high priority without jeopardising profitability. A significant part of this system is focused towards the use and man...
The main cause of human infectious diseases and public health threats these days has been thought to be “emerging and re-emerging diseases” such as BSE, highly pathogenic avian influenza (HPAI), SARS, etc. These infectious diseases were derived from pathogens from animals (zoonosis) and their products (food-borne infections). Recent zoonoses worldwide are reviewed here by origin, environment an...
Trends in fat consumption I read the paper ‘Trends in individual fat consumption in the UK 1900-1985’ by A. M. Stephen and G. M. Sieber (1994) with interest. This is an important subject for anyone concerned with possible links between fat consumption and chronic disease, especially in view of the intense educative activity about dietary fats that is now being encouraged. Try as I may, I cannot...
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