Three novel indole-based ligand precursors [HIndPh(R), R = methoxy, HIndPh(OMe) (); thiomethoxy, HIndPh(SMe) (); and N,N'-dimethylamino, HIndPh(NMe2) ()] have been synthesized via Sonogashira and cyclization reactions with moderate to high yield. Reactions of these ligand precursors with 0.6 equivalent of Mg(n)Bu2 in THF afforded the magnesium bis-indolyl complexes , respectively. All the ligan...

Increasing amounts of magnesium in LaCu intermetallic are shown to bring drastic electronic, chemical and mechanical changes. Based on DFT methodologies this is quantified for the cohesive energies, relative charge transfers, bulk modules, electronic structures and bonding properties for the three compounds LaCu, LaCuMg and LaCuMg4. Particularly the cohesive energies increase with Mg amounts: T...

Although magnesium fulfills several essential biochemical roles, direct studies on this ion are complicated by its unfavorable spectroscopic characteristics. This contribution explores the possibility of monitoring magnesium-nucleic acid binding via a combination of [Co(NH3)6]3+ as surrogate for [Mg(H2O)6]2+, and of high-resolution solid-state 59Co NMR as a spectroscopic probe. Such strategy qu...

Though s-block organometallics are indispensable tools in synthetic chemistry, their impact homogeneous catalysis has been small compared to that for transition metals. Surprisingly, however, Group 1 and 2 compounds have recently utilised hydroelementation catalysis. For example, transfer hydrogenation of alkenes alkanes catalysed by (Ca, Sr, Ba) bis-hexamethyldisilazides (HMDS), though reactio...

Concerning my hypothesis of efficacy of magnesium throat lozenges as a rapid acting rescue treatment for asthma as I described in my 2006 article [1] published in this journal, I only worked with adults that had allergy-induced asthma. I did not work with infants or children. There is an important difference between the asthma of adults and that of the pediatric age group. Adult asthma is belie...

A number of oral preparations of various forms of silicon were fed to young adult Beagle dogs and young rats of both sexes for a period of four weeks. During the test period the animals were observed for clinical symptoms and urine and blood measurements were made. At the end of the experimental period all animals were sacrificed and subjected to a complete necropsy and histopathologic study. P...

Magnesium alloys as biodegradable metal implants have received a lot of interest in biomedical applications. However, magnesium alloys have extremely high corrosion rates a in physiological environment, which have limited their application in the orthopedic field. In this study, calcium phosphate compounds (Ca-P) coating was prepared by arginine-glycine-aspartic acid-cysteine (RGDC) peptide-ind...

The reaction mixture of magnesium chloride with two equivalents of potassium anthranilate [K+ AnthÐ] in water gives on cooling to 0 ∞C a 60% yield of a precipitate which after drying in a vacuum has the composition [Mg(H2O)6](Anth)2 (1). Recrystallization from hot water affords an octahydrate identified as [Mg(H2O)6](Anth)2(H2O)2 (2) in a single crystal X-ray diffraction study. Contrary to find...

HCV-induced hepatitis is one of the most debilitating diseases. The limited number of anti-HCV drugs and drug-resistance necessitate developing of new scaffolds with different mode of actions. HCV non-structural protein 5B (NS5B) is an attractive target for development of novel inhibitors of HCV replication. In this paper, new N'-arylidene-6-(benzyloxy)-4-oxo-1,4-dihydroquinoline-3-carbohydrazi...