BACKGROUND Malignant hyperthermia (MH), a pharmacogenetic disorder of skeletal muscle, presents with a potentially lethal hypermetabolic reaction to certain anesthetics. However, some MH-susceptible patients experience muscle weakness, fatigue, and exercise intolerance in the absence of anesthetic triggers. The objective of this exploratory study was to elucidate the pathophysiology of exercise...

Localized magnetic hyperthermia using magnetic nanoparticles (MNPs) under the application of small magnetic fields is a promising tool for treating small or deep-seated tumors. For this method to be applicable, the amount of MNPs used should be minimized. Hence, it is essential to enhance the power dissipation or heating efficiency of MNPs. Several factors influence the heating efficiency of MN...

Magnetic nanoparticle-conjugated polymeric micelles (MNP-PMs) consisting of poly(ethylene glycol)-poly(lactide) (PEG-PLA) and iron oxide nanoparticles were prepared and used as nanocarriers for combined hyperthermia and chemotherapy. Doxorubicin (DOX) was encapsulated in MNP-PMs, and an alternating magnetic field (AMF) resulted in an increase to temperature within a suitable range for inducing ...

Colloidal nanocrystal assemblies (nanoclusters), consisting of 13 nm iron oxide nanocrystals, were synthesized in various sizes (45-98 nm), and were investigated as heating mediators for magnetic particle hyperthermia. The colloidal nanocrystal clusters show enhanced heating efficiency in comparison with their constituent primary iron oxide nanocrystals due to collective magnetic features. The ...

basic physical principles of nuclear magnetic resonance imaging (n.m.r.i), a nonionizing medical imaging technique, are described. principles of nmri with other conventional imaging methods, ie, isotope scanning, ultrasonography and radiography have been compared. t1 and t2 and spin density (s.d.) factors and different image construction techniques based on their different combinations is discu...

mri workers are occupationally exposed to static and time-varying gradient magnetic fields.  while the 24-hour time-averaged exposure to static magnetic fields is about a few mt, the maximum static field strength can be as high as 500 mt during patient set up. over the past several years, our lab has performed extensive experiments on the health effects of exposure of animal models and humans t...

Thirty pathologically diagnosed patients with grade III-IV primary or recurrent malignant glioma (tumor diameter 3-7 cm) were randomly divided into two groups. The control group underwent conventional radiotherapy and chemotherapy. In the hyperthermia group, primary cases received hyperthermia treatment, and patients with recurrent tumors were treated with hyperthermia in com-bination with radi...

Bone Tumor Suppression Magnetic bone cement incorporating magnetically soft zinc ferrite nanoparticles and aligned in a direct current magnetic field realized exceptionally high heating power live animals under clinically safe parameters for hyperthermia. of osteosarcoma rabbits by hyperthermia substantially enhances survival rate. More details can be found article number 2104626 Shuli He, Qing...

BACKGROUND AND PURPOSE Investigating focal cerebral ischemia requires animal models that are relevant to human stroke. Complications and side effects are common among these models. The present study describes potential pitfalls in 3 techniques for middle cerebral artery occlusion (MCAO) in rats using magnetic resonance imaging (MRI) and magnetic resonance angiography (MRA). METHODS Rats were ...

Modern challenges of food science require a new understanding of the determinants of food quality and safety. Application of advanced imaging modalities such as magnetic resonance imaging (MRI) has seen impressive successes and fast growth over the past decade. Since MRI does not have any harmful ionizing radiation, it can be considered as a magnificent tool for the quality control of food prod...