In an object oriented, distributed environment, program maintenance, which has never been the most predictable task, becomes even more uncertain. Java’s dynamic loading mechanism was developed to tackle some of the uncertainties. In doing so, it shifts the focus from the state of the sources to that of the binaries. This paper discusses some of the implications of that move.

In an object oriented, distributed environment, program maintenance, which has never been the most predictable task, becomes even more uncertain. Java’s dynamic loading mechanism was developed to tackle some of the uncertainties. In doing so, it shifts the focus from the state of the sources to that of the binaries. This paper discusses some of the implications of that move.

Passage through the Retinoblastoma protein (RB1)-dependent restriction point and the loading of minichromosome maintenance proteins (MCMs) are two crucial events in G1-phase that help maintain genome integrity. Deregulation of these processes can cause uncontrolled proliferation and cancer development. Both events have been extensively characterized individually, but their relative timing and i...

In this paper we motivate and describe materialized views, their applications, and the problems and techniques for their maintenance. We present a taxonomy of view maintenance problems based upon the class of views considered, upon the resources used to maintain the view, upon the types of modifications to the base data that are considered during maintenance, and whether the technique works for...

This article investigates a JIT single machine scheduling problem with a periodic preventive maintenance. Also to maintain the quality of the products, there is a limitation on the maximum number of allowable jobs in each period. The proposed bi-objective mixed integer model minimizes total earliness-tardiness and makespan simultaneously. Due to the computational complexity of the problem, mult...

The Ku70-Ku80 heterodimer is a conserved protein complex essential for the non-homologous end-joining pathway. Ku proteins are also involved in telomere maintenance, although their precise roles remain to be elucidated. In fission yeast, pku70(+), the gene encoding the Ku70 homologue, has been reported. Here we report the identification and characterization of pku80(+), the gene encoding Ku80. ...