Aims—To investigate the types and the frequencies of H-ras-1 gene mutations in malignant fibrous histiocytomas. Methods—Thirty five samples of malignant fibrous histiocytoma tissue were searched for point mutations within “hot spot” codons 12 and 13 of the H-ras-1 oncogene by the specific “nested” polymerase chain reaction followed by restriction fragment length polymorphism (PCR-RFLP) and a di...

Malignant fibrous histiocytoma (MFH) cases are classified within the group of nonclassified sarcomas. The etiopathogenesis is unclear; however, MFH commonly develops in scar tissue and in areas exposed to radiation. MFH is the most common soft tissue sarcoma in adults and may be borne in the lungs, chest wall, mediastinum, or other tissues. Primary MFH of the lung constitutes less than 0.2% of ...

A 60-year-old man, with a history of hypercholesterolemia and left leg deep vein thrombosis, was admitted to hospital following two weeks of headaches and expressive aphasia. Neurological examination confirmed expressive aphasia in the absence of motor, sensory or cranial nerve deficit. A total body computer tomography (CT) imaging showed a single intraparenchymal lesion with a central necrotic...

AIMS To investigate the types and the frequencies of H-ras-1 gene mutations in malignant fibrous histiocytomas. METHODS Thirty five samples of malignant fibrous histiocytoma tissue were searched for point mutations within "hot spot" codons 12 and 13 of the H-ras-1 oncogene by the specific "nested" polymerase chain reaction followed by restriction fragment length polymorphism (PCR-RFLP) and a ...

We report a case of primary malignant fibrous histiocytoma of the kidney. Primary involvement of the kidney is rare, with only 8 cases reported in the literature. This malignant mesenchymal tumor is indistinguishable clinically and radiologically from renal cell carcinoma.