OBJECTIVES To review the literature on antidepressant-induced mania, its incidence, clinical presentation, risk factors and treatment. METHODS A Medline search of studies published between 1970 and 2001 was carried out. Open and controlled studies as well as case series with data from more than five patients were included. RESULTS Antidepressant induced mania may differ clinically from spon...

BACKGROUND Markers of immune activation have been associated with mania but have not been examined in combination. We studied the association between mania and an inflammation score based on four immune markers. METHODS A total of 57 individuals with mania were assessed at up to three time points: the day of hospital admission, evaluation several days later, and six-month follow-up. Also asse...

Objective: According to DSM-5, bipolar disorder is a condition in which the patient experiences one or several manic episodes and sometimes major depressive episodes too. The signs and symptoms of the disorders in DSM are generally influenced by cultural and ethnic factors. Therefore, the present study was aimed at identifying the clinical manifestations of mania in bipolar I disorder in Irania...

In an open trial on manic patients, side-effects of carbamazepine, lithium and haloperidol were evaluated weekly over a 4-week period. The total side-effects with the three drugs were not significantly different, but the rate of amelioration of the same was best for lithium and least for haloperidol. It was indicative that lithium was better tolerated drug than the other two.

background: second-generation antipsychotics, approved for the treatment of mania, are associated with adverse effects such as weight gain and metabolic disorders. aripiprazole, a recently introduced second-generation antipsychotic, are thought to account for its low propensity for weight gain, metabolic disturbances and sedation. the purpose of this study was to investigate the effect of rispe...

INTRODUCTION Despite its controversial history, electroconvulsive therapy is generally an effective treatment with few serious side effects. One rare but troublesome side effect of electroconvulsive therapy is mania. CASE PRESENTATION A 33-year-old Turkish woman developed mania on three separate occasions after receiving electroconvulsive therapy for severe depressive episodes. CONCLUSION P...

Sir: In the only 2 studies that estimate prevalence of mania secondary to traumatic brain injury (TBI), Jorge et al. diagnosed mania in 9% of 66 consecutive brain-injured patients and Van Reekum et al. found 22% of 18 TBI patients developed a bipolar spectrum disorder after mild or moderate TBI. Both of these estimates are higher than the known lifetime prevalence of bipolar I disorder, which i...

Following the recent debates on the discrepancy between the predominant weight of bipolar disorder (BPD) in the clinical reality and its relatively low prevalence figures emerging from epidemiological surveys, the present paper contends the ability of current operational diagnostic system to properly detect the clinical entity of bipolar disorder.As an episode of mania/hypomania is the necessar...

Written records have been describing extreme states of emotions since ancient Greece (Angst and Marneros, 2001), but Aretaeus of Cappadocia (which is geographically located in modern Turkey) was probably the first to outline the close relationship between depression and mania nearly 2000 years ago: "I think that melancholia is the beginning and a part of mania. . . The development of mania is r...