2-Aminoquinolin-4(1H)-one was reacted with various primary/secondary amines and paraformaldehyde under Mannich reaction conditions. In the case of secondary amines, the reaction in N,N-dimethylformamide yielded expected Mannich products accompanied with 3,3'-methylenebis(2-aminoquinolin-4(1H)-one). Except these main products, the pyrimido[4,5-b]quinolin-5-one derivative was also identified as c...

Structural properties of two model solid Schiff-Mannich bases: 7-[(1-{5-bromo-3[(diethylamino)methyl]-2-hydroxyphenyl}methylidyne)amino]-4-methylcoumarin and N,N -bis{5-bromo-3-[(diethylamino)methyl]salicylidene}-1,2-diaminoethane have been investigated. In both cases a neutral intramolecular O–H...N hydrogen bonding is formed with participation of the Schiff parts of the molecules only. Single...

A new series of Mannich bases MK8-12 has been synthesized from 1, 2, 4thiadiazole by Mannich reaction. All the synthesized compounds of the series displayed, remarkable analgesic activity in comparison to standard drug diclofenac sodium. In the synthesized thiadiazole derivatives MK-8 & MK-10 showed activity at 20mg/kg . MK-9 & MK-11 are considered as most active compounds as they protected 60....

Three new 1,3,4-oxadiazole, 1,3-thiazolidine and 1,2,4-triazole derivatives were obtained starting from furan-2-carbohydrazide. Then, 1,2,4-triazole compound was converted to the corresponding Mannich bases using several secondary amines including piperidine, piperazine, morpholine or thiomorpholine moiety. The synthesis of 5-(furan-2-yl)-4-{[(4-methoxyphenyl)methylidene]amino}-4H-1,2,4-triazol...

Inhibition of acetylcholinesterase and butyrylcholinesterase (AChE and BuChE) as two major forms of cholinesterases (ChEs) is considered as the common approach for the treatment of Alzheimer's disease (AD). The present study was done to explore the anticholinesterase inhibition property of coumarin Mannich base derivatives. A series of cumarin Manich bases were synthesized (4a-h) through one-po...

A series of Mannich bases 5a-5h were synthesized by the reaction of 5–{2–(ethylthio)–1H– benzimidazol–1–yl}–methyl–1,3,4–oxadiazole–2–thione 4 with formaldehyde and appropriate amines by conventional and microwave techniques. The reaction rate and yields were enhanced under microwave irradiation technique rather than conventional technique. Structures were characterized by means of spectral dat...

Two consecutive measurements of the position of a non relativistic free particle will give entirely unrelated results. Recent quantum information research by G. Svetlichny, J. Tolar, and G. Chadzitaskos have explained this property of position observables as a result of a path in the Feynman integral being mathematically defined as a product of incompatible states; that is, as a product of mutu...

Benzamido (alkyl) methyl pyrrolidine Mannich bases were synthetized and subjected to certain neuropharmacological studies. All the bases reduced the pentobarbitone sleeping time and rota-rod grip of rats. The Mannich bases II, III and V raised the minimal electro-shock seizure threshold of rats. The TAB-induced pyrexia was not reduced by the bases I and III in rabbits. None of the bases showed ...

A catalytic enantioselective method for the synthesis of α-quaternary Mannich-type products is reported. The two-step sequence of (1) Mannich reaction followed by (2) decarboxylative enantioselective allylic alkylation serves as a novel strategy to in effect access asymmetric Mannich-type products of "thermodynamic" enolates of substrates possessing additional enolizable positions and acidic pr...

1,2,4-Triazole-3-one (3), acquired from cinnamaldehyde was converted to the corresponding carbox(thio)amides via several steps (6 a–c). Their reaction with sodium hydroxide gave 1,2,4-triazole derivatives (7 Compound 3 treatment 2-bromo-1-(4-chlorophenyl) ethanone or 2-chloro-1-(2,4-dichlorophenyl)ethanone afforded compounds 8 a,b and by reducing these reduction products were obtained (9 a,b). ...