The virulence of fungi is dependent on multiple factors, including the immune status of patients and biological features of fungi. In particular, the virulence of Aspergillus fumigatus is due to the complex interaction among various molecules involved in thermotolerance (such as ribosomal biogenesis proteins, α-mannosyltransferase and heat shock proteins), pigment production (DHN-melanin), immu...

The capsule of the fungal pathogen Cryptococcus neoformans has been studied extensively in recent decades and a large body of information is now available to the scientific community. Well-known aspects of the capsule include its structure, antigenic properties and its function as a virulence factor. The capsule is composed primarily of two polysaccharides, glucuronoxylomannan (GXM) and galacto...

Cava lees are a sparkling wine by-product formed of dead microorganisms, tartaric acid and other inorganic compounds, with potential for enhancing microbial growth. Lees rich in antioxidant compounds as well ?-glucans mannoproteins. The aim this study was to evaluate the effect different concentrations cava (0–2% w/w) on microbiota (LAB yeasts) responsible sourdough fermentation (8 days) revalo...

Mannoproteins, as the main constituents of the outer layer of yeast cell walls, are able to interact with phagocytic cells in an opsonin-independent manner through the mannose receptor (MR) and to induce yeast ingestion by the professional phagocytes. Moreover, the MR also mediates endocytosis of soluble ligands through clathrin-coated pits. Here, we studied some aspects of the interaction betw...

An extracellular matrix composed of a layered meshwork of beta-glucans, chitin, and mannoproteins encapsulates cells of the yeast Saccharomyces cerevisiae. This organelle determines cellular morphology and plays a critical role in maintaining cell integrity during cell growth and division, under stress conditions, upon cell fusion in mating, and in the durable ascospore cell wall. Here we asses...

A study was conducted to determine the effect of the Candida albicans mannoprotein on Phagocytic activity, antibody production, serum gammaglobuline percentage and lymphocyte transformation index after vaccination with hepatitis B surface (HBs) antigen. It can be concluded that Mannoprotein isolated from Candida albicans cell wall are an important immunomodulatorts in the development of immune ...

Until recently, the diagnosis of systemic mycoses was mainly based on traditional methods producing late and inconclusive results. Currently used methods of serological diagnostics are generally based on detection of cell wall components of selected pathogenic fungal species--mannoproteins, functioning as a antigenic markers. There are big hopes for adaptation of commercially available assays t...

While mannosylation targets antigens to mannose receptors on dendritic cells (DC), the resultant immune response is suboptimal. We hypothesized that the addition of toll-like receptor (TLR) ligands would enhance the DC response to mannosylated antigens. Cryptococcus neoformans mannoproteins (MP) synergized with CpG-containing oligodeoxynucleotides to stimulate enhanced production of proinflamma...