Purpose: Blood-derived biomarkers have been extensively considered as possible prognostic indicators in idiopathic pulmonary fibrosis (IPF) recently. In order to assess the value of circulating common IPF clinical practice, study intends draw conclusions regarding link between disease severity, indicators, and serum matrix metalloproteinase patients with stable fibrosis.
 Materials Methods...

Background Astragalus polysaccharide (APS) had shown great promise in anti-tumour activities our previous studies. The present study was designed to investigate whether APS has synergistic effect with cisplatin on the growth-inhibitory of human nasopharyngeal carcinoma cell lines and possible mechanism. Methods Here, (CNE-1) were divided into CNE-1 group, Cisplatin treatment group (2 µg/mL Cisp...

Amphiregulin (AR) and epidermal growth factor effects on expression and activity of the extracellular matrix metalloproteinase inducer (EMMPRIN) were examined in NS2T2A1 breast tumor cells. Both growth factors induced mRNA and protein expression of EMMPRIN, and matrix metalloproteinase (MMP) -2 and -9 enzymatic activity. The induction of EMMPRIN by AR was mediated by epidermal growth factor rec...

Amphiregulin (AR) and epidermal growth factor effects on expression and activity of the extracellular matrix metalloproteinase inducer (EMMPRIN) were examined in NS2T2A1 breast tumor cells. Both growth factors induced mRNA and protein expression of EMMPRIN, and matrix metalloproteinase (MMP) -2 and -9 enzymatic activity. The induction of EMMPRIN by AR was mediated by epidermal growth factor rec...

objective(s): osteoarthritis (oa), as a known degenerative joint disease, is the most common form of arthritis. in this study, we aimed to elucidate unclear pathogenesis of oa. materials and methods: rabbit models of oa were established by the transection of the anterior cruciate ligament. rabbits were randomly divided into three equal groups: the experimental group (oa modeling, treated with e...

Abstract Background Meningiomas are common primary brain neoplasms. CD44 is a cell surface glycoprotein receptor that involved in matrix-mediated signaling and cell–matrix adhesion. Matrix metalloproteinase-9 (MMP-9) plays important role angiogenesis tumor invasion. The expression of protein membranous cytoplasmic (CD44M CD44C) has been reported several tumors (such as lobular carcinoma, renal ...