INTRODUCTION McCune-Albright syndrome is a complex inborn disorder due to early embryonal postzygotic somatic activating mutations in the GNAS1 gene. The phenotype is very heterogeneous and includes polyostotic fibrous dysplasia, typically involving the facial skull, numerous café-au-lait spots and autonomous hyperfunctions of several endocrine systems, leading to hyperthyroidism, hypercortisol...

Four year old girl was evaluated for precocious puberty. Breast development and pubic hair growth had started at age 2½ year, and had been followed by vaginal bleeding resembling periods. Gaf-au-lait spots were present in most of her skin surface. Bone x-rays showed multiple cysts in pelvis and the metaphysis of femur. Diagnosis of McCune-Albright syndrome was made. Concentrations of all hormon...

M. Murakami, M.R. Wade, J.C. DeBoo, C.M. Greenfield, T.C. Luce, M.A. Makowski, C.C. Petty, G.M. Staebler, T.S. Taylor, M.E. Austin, D.R. Baker, R.V. Budny, K.H. Burrell, T.A. Casper, M. Choi, J.R. Ferron, A.M. Garofalo, I.A. Gorelov, R.J. Groebner, R. La Haye, A.W. Hyatt, R.J. Jayakumar, K. Kajiwara, J.E. Kinsey, L.L. Lao, J. Lohr, D. McCune, R.I. Pinsker, P.A. Politzer, R. Prater, ( b ) H.E. S...

In 1952 the clinical use of pyrazinamide (PZA) was first reported by Yeager, Munroe, and Dessa&. In 1954 McCune, Tompsett, and McDermott2 observed that the combined use of isoniazid and pyrazinamide in the treatment of pulmonary tuberculosis was especially effective. Isoniazid (INH) and pyrazinamide have been employed at the San Fernando Veterans Administration Hospital since 1952, but not unti...

K. Keahey T. Fredian Q. Peng D. P. Schissel M. Thompson I. Foster 5 M. Greenwald D. McCune 1 Mathematics and Computer Science Division, Argonne National Laboratory, Argonne, IL 60439 2Plasma Science and Fusion Center, MIT, Cambridge, MA 02139 3General Atomics, P.O. Box 85608, San Diego, California, 92186-5608 4Lawrence Berkeley National Laboratory, Berkeley, CA 94720 5 Department of Computer Sc...