The dermatological disease Molluscum contagiosum (MC) presents as lesions restricted solely to the skin. The poxvirus Molluscum contagiosum virus (MCV) is responsible for this skin disease. There are four subtypes of MCV: MCV-1; MCV-2; MCV-3; and MCV-4. MCV-1 is the most commonly reported subtype found. The MCV MC159 protein belong to a family of proteins known as FLICE; FADD-like interleukin-1...

Merkel cell polyomavirus (MCV) causes an aggressive human skin cancer, Merkel cell carcinoma, through expression of small T (sT) and large T (LT) viral oncoproteins. MCV sT is also required for efficient MCV DNA replication by the multifunctional MCV LT helicase protein. We find that LT is targeted for proteasomal degradation by the cellular SCF(Fbw7) E3 ligase, which can be inhibited by sT thr...

UNLABELLED Merkel cell polyomavirus (MCV) is a newly discovered human cancer virus encoding a small T (sT) oncoprotein. We performed MCV sT FLAG-affinity purification followed by mass spectroscopy (MS) analysis, which identified several protein phosphatases (PP), including PP2A A and C subunits and PP4C, as potential cellular interacting proteins. PP2A targeting is critical for the transforming...

Previous studies have shown that melanoma patients develop an im mune response to cell surface melanoma-associated antigens. The pres ence of this antibody response to cell surface antigens has been correlated with a better clinical outcome when melanoma patients are treated with an allogeneic melanoma cell vaccine (MCV) as an active immunotherapy protocol. It was hypothesized that the inabilit...

زمینه و هدف: بیماری آلزایمر با کاهش نورون‌ها در چندین منطقة مهم برای حافظه یادگیری مغز، ‌به‌ویژه هیپوکامپ مرتبط است. اختلال مغزی پیشرونده‌ای است که به‌صورت تدریجی سبب از بین رفتن حافظه، توانایی آموختن برقراری رابطه دیگران می‌شود. پژوهشگران مشاهدة میزان ابتلای یک‌ونیم برابری افراد دیابتی به آلزایمر، این دیدگاه را ممکن نشان‌دهندة نوع خاصی دیابت مغز باشد، مطرح کرده‌اند؛ هرچند پذیرش تقسیم‌بندی عنوا...

Koljonen et al described an association between chronic lymphocytic leukemia (CLL) and Merkel cell polyomavirus (MCV)– positive Merkel cell carcinoma (MCC) in a recent large populationbased survey from Finland.1 CLL has been reported as a tumor significantly associated with MCC, validating the general findings of this study.2,3 This association suggests the possibility that MCV may play a role ...

Merkel cell carcinoma (MCC) is a neuroendocrine skin cancer associated with high mortality. Merkel cell polyomavirus (MCV), discovered in 2008, is associated with ~80% of MCC. The MCV large tumor (LT) oncoprotein upregulates the cellular oncoprotein survivin through its conserved retinoblastoma protein-binding motif. We confirm here that YM155, a survivin suppressor, is cytotoxic to MCV-positiv...

The Merkel cell polyomavirus (MCV) is involved in the development of up to 100% of Merkel cell cancer (MCC) cases. Early studies have reported that the virus was infrequently detected in other small cell or neuroendocrine lung carcinomas, which share histological features with MCC. The present study investigated the presence of MCV in cases of extrapulmonary small cell carcinoma (ESCC), which a...

Merkel cell carcinoma (MCC) is a rare and highly aggressive skin cancer associated with the Merkel cell polyomavirus (MCV). As MCC cell lines show oncogene addiction to the MCV T antigens, pharmacologic interference of the large T antigen (LTA) may represent an effective therapeutic approach for this deadly cancer. In this study, we investigated the effects of IFNs on MCC cell lines, especially...

INTRODUCTION Autoantibodies against mutated and citrullinated vimentin (MCV) represent a novel diagnostic marker for rheumatoid arthritis (RA). Recently, an increased sensitivity for anti-MCV compared to autoantibodies against cyclic citrullinated peptides (anti-CCP2) was shown in cohorts of patients with early RA and established disease.The aim of this study was to develop and evaluate a point...