Tamoxifen (Tam), a selective estrogen receptor modulator, is in wide clinical use for the treatment and prevention of breast cancer. High Tam doses have been used for treatment of gliomas and cancers with multiple drug resistance, but long QT Syndrome is a side effect. Tam is also used experimentally in mice for inducible gene knockout in numerous tissues, including heart; however, the potentia...

The aim of this study was to examine how global cardiac gene transfer of sarcoplasmic reticulum Ca(2+)-ATPase (SERCA2a) can influence left ventricular (LV) mechanical and energetic function, especially in terms of O(2) cost of LV contractility, in normal rats. Normal rats were randomized to receive an adenovirus carrying the SERCA2a (SERCA) or beta-galactosidase (beta-Gal) gene or saline by a c...

The problem of metal corrosion resulting from contamination by palmar sweat is common to many industrial occupations. Constant handling of metal parts by some individuals causes an accumulation of rust (Fig. 1). In the manufacture of highlyfinished metal products, for example ball-bearings, and also in subsequent assembling and packing processes, serious consideration must be given to this effe...

There is consensus that registered nurses worldwide have a high prevalence of work-related musculoskeletal disorders, particularly of the back. Patient handling activities such as lifting present the highest risk of injury, activities that begin in nursing school. A literature review identified 21 studies of back pain in nursing students, indicating a wide range of prevalence rates. A prospecti...

III Einstein International Symposium on Intensive Care and the XXX Mechanical Ventilation. Aug 16-18, 2023. Category: Safety / Quality Management Introduction: Ventilation (MV) is a fundamental clinical support for maintaining life in severe conditions of respiratory failure.() Therefore, management critical patients MV by nurse, member multidisciplinary team, extremely important achieving ther...

A strategy to protect Tamm plasmon optical detectors from mechanical stress and handling by adding a sol–gel porous oxide overlayer is demonstrated. The sensing properties of the protected devices are also shown.

This work focuses on web dynamics and wrinkles analysis in industrial web handling systems by using finite element modeling. The main objective is to simulate wrinkles in a real environment with the control part of the system, depending on mechanical parameters and process data. The effects of misaligned rollers and a roller deflection are specifically analyzed in order to study the influence o...

No part of this publication may be reproduced, stored in a retrieval system, or transmitted in any form or by any means, electronic, mechanical, photocopying, recording , or otherwise, without the prior permission of Springer Publishing Company, Inc. Safe patient handling and movement : a guide for nurses and other health care providers / edited by Audrey L. Nelson. p. ; cm. Includes bibliograp...