Cell-mediated immune responses in patients who had recovered from cryptococcosis were compared to those of healthy subjects. Cryptococcal patients were mildly lymphopenic but showed no defect in percentage of thymus-derived lymphocytes. One-third had positive delayed skin test reactions to cryptococcal antigen. Their skin test reactivity to two commonly used noncryptococcal antigen’s was less i...

1 Norwegian College of Fishery Science, Faculty of Biosciences, Fisheries and Economics, University of Tromso, 9037 Tromso, Norway 2Nofima, Muninbakken 9-13, 9291 Tromso, Norway 3Division of Solid Tumor, Department of Medical Oncology, Thomas Jefferson University, Philadelphia, PA 19107, USA 4 Janssen Research & Development, LLC, Immunology Discovery, 3210 Merryfield Row, San Diego, CA 92121, U...

Evidence is presented which reinforces the complexity of the host-parasite interaction during the course of syphilis. Infection with Treponema pallidum evokes a complicated antibody response and an assortment of cell-mediated immune reactions in the host. It appears that humoral immunity plays a minor role towards the complete elimination of syphilitic infection while the cellular limb of the i...

A murine respiratory challenge model was used to examine the induction of cellular and humoral immune responses and their role in protection against BordeteUla pertussis following immunization or previous infection. Spleen cells from mice convalescing from a B. pertussis infection exhibited extensive in vitro T-cell proliferation and secreted high levels of interleukin-2 (IL-2) and gamma interf...

Immunotherapy is emerging as a promising alternative treatment for variety of solid tumors. Its beneficial effects are mediated through hijacking the immune system to mount an anti-tumor response. One mechanisms increasing anti-tumour immunity checkpoint blockade.