We propose an extension to current view-based mediator systems called model-based mediation, in which views are defined and executed at the level of conceptual models (CMs) rather than at the structural level. Structural integration and lifting of data to the conceptual level is “pushed down” from the mediator to wrappers which in our system export classes, associations, constraints, and query ...

The Mediator-related transcription co-factors integrate positive and negative inputs and recruit and activate the RNA polymerase II complex. To understand the role of Mediator during transcription, it is important to identify Mediator subunits that are essential for its functions. In the yeast Mediator, the conserved component Rgr1 is associated with multiple subunits that are required for spec...

Regulated intramembrane proteolysis of the amyloid precursor-protein (APP) produces both a characterstic amyloid-β peptide that contributes to neuritic plaque formation and neurodegeneration in Alzheimer disease and a small APP intracellular domain (AICD) that transcriptionally activates genes implicated in Alzheimer disease pathology. Although the biochemical events leading to amyloidogenic AP...

An approach for extensible ontological model construction in a mediation environment intended for heterogeneous information sources integration in various subject domains is presented. A mediator ontological language (MOL) may depend on a subject domain and is to be defined at the mediator consolidation phase. On the other hand, for different information sources different ontological models (la...

We propose a model for providing integrated and unified access to multiple information sources. Each information source comprises two parts: (a) an ontology i.e. a set of terms structured by a subsumption relation, and (b) a database that stores objects under the terms of the ontology. We assume that the objects of interest belong to an underlying domain that is common to all sources (e.g. a se...

The number of online information sources is growing rapidly. Though much of this information is unstructured (e.g., text, images) the number of structured information sources (e.g., databases) is also increasing. The advantage of structured information sources is that we can actually query their contents and use them to answer queries, perhaps in combination with other structured sources, rathe...

We use a context interchange mediation approach for detecting and resolving data quality and semantic integrity conflicts in information exchanged across organizational boundaries. Context models draw on a domain ontology to explain how source and receiver data models implement general principles of the subject domain. Using the declarative knowledge from the domain ontology and context models,...

An essential element in defining the semantics of Web services is the domain knowledge. Medical informatics is one of the few domains to have considerable domain knowledge exposed through standards. These standards offer significant value in terms of expressing the semantics of Web services in the healthcare domain. In this paper, we describe the architecture of the Artemis project, which explo...

nowadays with high competition in area of business, companies have to use different strategies in order to face and control this competition. without doubt not only use of these strategies influences on packaging but also this issue affect on companies’ performance. hence, aim of this research is to study differentiation strategy of porter as a competitive strategy on organizational performance...