Copyright: © 2014 Panda S, et al. the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. Our understanding of melasma as a disease has undergone a radical shift in the past decade or two [1]. The landmark paper by Sanchez et al. published in 1981 first provided for...

BACKGROUND Low-fluence 1064 nm Q-switched Nd:YAG laser has recently been shown to be effective for the melasma treatment. OBJECTIVE The purpose of this study is to evaluate the clinical efficacy and safety of low-fluence 1064 nm Q-switched Nd:YAG laser treatment of melasma in Asian patients. METHODS Fifty patients with melasma underwent 15 weeks of weekly treatments, using a Q-switched Nd:Y...

BACKGROUND Melasma is difficult to treat and often recalcitrant to various treatments such as topical preparations and lasers. OBJECTIVES To evaluate the efficacy and safety of the 1064-nm Q-switched Nd:YAG laser in Asian patients with melasma. METHODS Twenty-three Korean patients (skin types III-V) with melasma were treated with the 1064-nm Q-switched Nd:YAG laser at 1-week intervals for 1...

Purpose: To determine the effectiveness of external application Jidesheng snake tablets, trehalose glycerin mud, and hydroquinone cream in treatment melasma.
 Methods: The study was conducted on 60 patients with melasma who were treated Affiliated Yueqing Hospital Wenzhou Medical University between January 1, 2021, 31, 2022. randomly but equally assigned to two groups (study control). grou...

BACKGROUND Melasma poses a great challenge as its treatment is unsatisfactory and recurrence is high. Treatment of melasma using tranexamic acid (oral, topical or intralesional) is a novel concept. OBJECTIVE To compare the efficacy of oral tranexamic acid with routine topical therapies for the treatment of melasma. METHODS It is a prospective, interventional, randomized controlled trial con...

Background: Melasma is an acquired therapeutically problematicdisease characterized by symmetrical facial hypermelanosis. Theaim of this study was to evaluate the efficacy of azelaic acid20% cream in the treatment of melasma in Iranian patients andcompare it with hydroquinone 4% cream which has been thestandard treatment.Method: The study was an open clinical trial with a split-facedesign. All ...

A close contact between melanocytes and nerve fibers in the epidermis has been demonstrated in normal human skin. The interactions between the neural and immune systems play an important role in the pathophysiology of certain dermatoses. In this study, we investigated the intraepidermal nerve fibers and their contacts with melanocytes in the lesions of melasma using double labeled immunofluores...

Melasma is an acquired hypermelanosis characterized by the development of symmetrical, irregular light-to-dark brown macules and patches on sun-exposed areas of the skin, especially on the skin of the face [1]. It is common among Asian and Hispanic women who are in their third or fourth decades of life [2]. Three patterns of melasma are recognized clinically that are based on the distribution o...

Melasma represents a pigmentary disorder that is difficult to treat. This study aims to broadly review the use of ablative lasers (Er:YAG and CO2) in the treatment of melasma, presenting the level of evidence of studies published to date. A total of 75 patients were enrolled in four case series studies (n=39), one controlled clinical trial (n=6) and one randomized controlled clinical trial (n=3...

Background and aim: It seems that melanocytic nevi, freckle and lentigo are more common in women with melasma, and a common genetic background may exist. In this study the prevalence and number of lentigo, freckle and melanocytic nevus were compared in women with and without melasma.Materials and methods: In a case-control study, 120 women with melasma (case group) and ...