Delivering large molecules into the cytosol of animal cells without damaging the cells has been one of the toughest challenges in biology. Endo-Porter is a weak-base amphiphilic peptide that was designed to deliver morpholino antisense oligomers and other non-ionic substances into the cytosol/nuclear compartment of cells by an endocytosis-mediated process that avoids damaging the plasma membran...

The capacity for secondary effluent filtration of hollow fiber polypropylene membranes grafted with several zwitterionic molecules and multi-walled carbon nanotubes was evaluated. In particular, all the modifications result in significant improvement of filtration performances. The anti-fouling properties of the membrane had been increased without damaging the membrane as observed from FTIR, TG...

Abstract This review highlights the advantages of incorporating hexagonal Boron Nitride (BN) into current membrane-based architectures for water remediation over other well-explored 2D nanomaterials such as graphene, graphene oxide, molybdenum sulphide, MXenes. BN has an interlayer spacing 3.3A 0 which is similar to that but smaller than nanomaterials. bioinert, and stable under harsh chemical ...

NK cells kill sensitive targets via exocytosis of cytoplasmic granules containing membrane damaging perforins and DNA damaging granzymes. Therefore, the target cell can either die by necrosis or by apoptosis. A third, non-secretory, mechanism of killing mediated by Fas-FasL interaction can be used by activated NK cells to kill Fas+ targets. Here, we have studied the modulation exerted by two NK...

Oral habits, if persist beyond certain developmental age, can pose great harm to the developing teeth, occlusion, and surrounding oral tissues. In the formative years, almost all children engage in some non-nutritive sucking habits. Clinicians, by proper differential diagnosis and thorough understanding of natural growth and developmental processes, should take a decision for intervening. This ...

DNA damaging drugs interfere with transcription and reduplication. Affected cells respond with cell cycle arrest or programmed cell death. DNA damaging drugs are mutagenic, teratogenic, and carcinogenic. Adverse effects are exerted on rapidly proliferating cells (skin—hair loss, gastrointestinal tract—nausea and vomiting, bone marrow—anemia causing fatigue/leukopenia causing infections/thromboc...

The central nervous system (CNS) insults may cause massive demyelination and lead to the release of myelin-associated proteins including its major component myelin basic protein (MBP). MBP is reported to induce glial activation but its effect on neurons is still little known. Here we found that MBP specifically bound to the extracellular surface of the neuronal plasma membrane and induced neuro...

In retinal surgery clinicians access the internal volume of eyeball through small scale trocar ports, typically 0.65 mm in diameter, to treat vitreoretinal disorders like idiopathic epiretinal membrane and age-related macular holes. The treatment these conditions involves removal thin layers diseased tissue, namely limiting membrane. These membranes have an average thickness only 60 ?m 2 respec...

Curcumin, an important constituent of turmeric, is known for various biological activities, primarily due to its antioxidant mechanism. The present study focused on the antibacterial activity of curcumin I, a significant component of commercial curcumin, against four genera of bacteria, including those that are Gram-positive (Staphylococcus aureus and Enterococcus faecalis) and Gram-negative (E...

Enterococcus faecalis is a commensal bacterium of the mammalian intestine that can persist in soil and aquatic systems and can be a nosocomial pathogen to humans. It employs multiple stress adaptation strategies in order to survive such a wide range of environments. Within this study, we sought to elucidate whether membrane fatty acid composition changes are an important component for stress ad...