Episodic recollection entails the conscious remembrance of event details associated with previously encountered stimuli. Recollection depends on both the establishment of cortical representations of event features during stimulus encoding and the cortical reinstatement of these representations at retrieval. Here, we used multivoxel pattern analyses of functional magnetic resonance imaging data ...

Improving memory for studied items (targets) often helps participants reject nonstudied items (lures), a pattern referred to as the strength-based mirror effect (SBME). Criss (2010) demonstrated the SBME in diffusion model drift rates; that is, the target drift rate was higher and the lure drift rate was lower for lists of words studied 5 times versus lists of words studied once. She interprete...

objective: the cerebellum is a key structure involved in coordinated motor planning, cognition, learning and memory functions. this study presents a permanent model of a toxin produced cerebellar lesion characterized according to contemporary motor and cognitive abnormalities. materials and methods: in this experimental study, slow administration of quinolinic acid (qa, 5 μl of 200 μmol, 1 μl/m...

Synapses, points of contact between axons and dendrites, are conduits for the flow of information in the circuitry of the central nervous system. The strength of synaptic transmission reflects the interconnectedness of the axons and dendrites at synapses; synaptic strength in turn is modified by the frequency with which the synapses are stimulated. This modulation of synaptic strength, or synap...

The ACT-R theory (Anderson, 1993; Anderson & Lebiere, 1998) is applied to the list memory paradigms of serial recall, recognition memory, free recall, and implicit memory. List memory performance in ACT-R is determined by the level of activation of declarative chunks which encode that items occur in the list. This level of activation is in turn determined by amount of rehearsal, delay, and asso...

T cell memory plays a critical role in our protection against pathogens and tumors. The antigen and its interaction with the T cell receptor (TCR) is one of the initiating elements that shape T cell memory together with inflammation and costimulation. Over the last decade, several transcription factors and signaling pathways that support memory programing have been identified. However, how TCR ...

Anticipation of periodic events signalled by a time marker, or interval timing, has been explained by a separate pacemaker-counter clock. However, recent research has added support to an older idea: that memory strength can act as a clock. The way that memory strength decreases with time can be inferred from the properties of habituation, and the underlying process also provides a unified expla...