نتایج جستجو برای: mepscs

تعداد نتایج: 333  

Journal: :Proceedings of the National Academy of Sciences of the United States of America 1992
D A Prince C F Stevens

Adenosine, at concentrations ranging from 5 to 100 microM, decreases the efficacy of transmission at the perforant path synapses on dentate granule cells. We have used whole cell recording from these cells in slices to determine the mechanism of the reduced synaptic strength. We find that size of miniature excitatory postsynaptic currents (mepscs) is unaffected by adenosine at concentrations up...

Journal: :The Journal of neuroscience : the official journal of the Society for Neuroscience 1999
D Lee D K O'Dowd

Difficulty in recording from single neurons in vivo has precluded functional analyses of transmission at central synapses in Drosophila, where the neurotransmitters and receptors mediating fast synaptic transmission have yet to be identified. Here we demonstrate that spontaneously active synaptic connections form between cultured neurons prepared from wild-type embryos and provide the first dir...

Journal: :The Journal of neuroscience : the official journal of the Society for Neuroscience 2008
Deniz Atasoy Mert Ertunc Krista L Moulder Justin Blackwell ChiHye Chung Jianzhong Su Ege T Kavalali

In a synapse, spontaneous and action-potential-driven neurotransmitter release is assumed to activate the same set of postsynaptic receptors. Here, we tested this assumption using (+)-5-methyl-10,11-dihydro-5H-dibenzo [a,d] cyclohepten-5,10-imine maleate (MK-801), a well characterized use-dependent blocker of NMDA receptors. NMDA-receptor-mediated spontaneous miniature EPSCs (NMDA-mEPSCs) were ...

Journal: :Frontiers in bioscience 2015
Jun Guo Zhi-cheng Sun Pan-tong Yao Hong-li Wang Lei Xue

Although quantal release provides a basic control of synaptic strength, its underlying mechanisms remain unclear. Here, we report a refined realistic 3D vesicle fusion model at calyx-type synapses. By refining the micro ultrastructure and combining updated parameters, our model is appropriate for simulating quantal release. First, we confirmed the existence of kiss-and-run fusion and gave a jus...

Journal: :The Journal of pharmacology and experimental therapeutics 2003
Akira Kitamura William Marszalec Jay Z Yeh Toshio Narahashi

General anesthetics are thought to act on both excitatory and inhibitory neuronal pathways at both post- and presynaptic sites. However, the literature in these regards is somewhat controversial. The aim of the present study was to reassess the relative importance of the various anesthetic actions using a common preparation. Rat cortical neurons in primary culture were used to record spontaneou...

Journal: :Current neurovascular research 2013
Yan-Hai Li Jue Wang

N-methyl-D-aspartate receptors (NMDA-Rs) activation has been implicated in various forms of synaptic plasticity depending on the receptor subtypes involved. However, the contribution of NR2A and NR2B subunits in glycine-induced long-term potentiation (LTP) of miniature excitatory postsynaptic currents (mEPSCs) in layer II/III pyramidal neurons of the rat visual cortex remains unclear. The prese...

2016
Soroush Darvish-Ghane Manabu Yamanaka Min Zhuo

Dopamine (DA) possesses potent neuromodulatory properties in the central nervous system. In the anterior cingulate cortex, α-amino-3-hydroxy-5-methyl-4-isoxazole propionic acid receptors (AMPAR) are key ion channels in mediating nerve injury induced long-term potentiation (LTP) and chronic pain phenotype. In the present study, we reported the effects of DA on glutamate mediated excitatory post-...

Journal: :Journal of neurophysiology 2007
Anna K Läck Marvin R Diaz Ann Chappell Dustin W DuBois Brian A McCool

Withdrawal anxiety is a significant factor contributing to continued alcohol abuse in alcoholics. This anxiety is long-lasting, can manifest well after the overt physical symptoms of withdrawal, and is frequently associated with relapse in recovering alcoholics. The neurobiological mechanisms governing these withdrawal-associated increases in anxiety are currently unknown. The basolateral amygd...

Journal: :Journal of pharmacological sciences 2014
Orie Tomoyose Daisuke Kodama Hideki Ono Mitsuo Tanabe

Fluvoxamine, a selective serotonin (5-HT) reuptake inhibitor, has been shown to exert analgesic effects in humans and laboratory animals. However, its effects on spinal nociceptive synaptic transmission have not been fully characterized. Here, whole-cell recordings were made from dorsal horn neurons in spinal slices with attached dorsal roots from adult mice, and the effects of fluvoxamine on m...

2015
Angela Vandenberg David J. Piekarski Natalia Caporale Francisco Javier Munoz-Cuevas Linda Wilbrecht

The maturation of inhibitory circuits during adolescence may be tied to the onset of mental health disorders such as schizophrenia. Neurotrophin signaling likely plays a critical role in supporting inhibitory circuit development and is also implicated in psychiatric disease. Within the neocortex, subcircuits may mature at different times and show differential sensitivity to neurotrophin signali...

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