Dianionic [MO(MAG(3))](2-)(MAG(3) = penta-anionic form of mercaptoacetyltriglycine, M = (186)Re, (99m)Tc) complexes have important applications in nuclear medicine. In vivo the complexes have a deprotonated carboxyl group that is important to their biodistribution. The solid-state structures of (99)Tc and Re complexes with mercaptoacetyltriglycine reported previously are monoanions with protona...

Objectives: We have previously developed a renal expert system (RENEX) as a decision support tool to assist in the interpretation of Tc-99m MAG3 scans to detect renal obstruction in patients referred for diuresis renography. A decision support system may give the right answer for the wrong reasons. This study is to describe and evaluate a software engine to justify the conclusions reached by RE...

background: measurement of absolute or differential renal function using radiotracers plays an important role in the clinical management of various renal diseases. gamma camera quantitative methods in approximation of renal clearance may potentially be as accurate as plasma clearance methods. however some critical factors such as kidney depth and background counts are still troublesome in the u...

UNLABELLED Radioimmunotherapy (RIT) can be performed with various radionuclides. We tested the stability, biodistribution, and therapeutic efficacy of various radioimmunoconjugates ((131)I, (88/90)Y, (177)Lu, and (186)Re) of chimeric antirenal cell cancer monoclonal antibody G250 (mAb cG250) in nude mice with subcutaneous renal cell cancer (RCC) tumors. METHODS The (88/90)Y and (177)Lu labeli...

BACKGROUND Renal scintigraphy with radiolabeled pentetic acid (diethylenetriamine pentaacetic acid [DTPA]) or, more recently, mertiatide (mercaptoacetyltriglycine [MAG3]), with or without captopril challenge, is widely recommended as a diagnostic test for renal artery stenosis. OBJECTIVES To address (1) whether the diagnostic accuracy has been improved by the use of captopril and the introduc...

BACKGROUND Renal scans are among the most frequent exams performed on infants and toddlers. Due to the young age, this patient group can be classified as a high-risk group with a higher probability for developing stochastic radiation effects compared to adults. As there are only limited data on biokinetics and dosimetry in this patient group, the aim of this study was to reassess the dosimetry ...

BACKGROUND Experimental models are essential tools in the development and evaluation of novel treatment options, but the preclinical model of renal ischemia-reperfusion injury is limited to the retrieval of (very) early functional data, leaving the pivotal long-term outcome unknown. The present study applies technetium-99m-mercapto-acetyl-tri-glycine [99mTc-MAG3] scintigraphy for the longitudin...