Year 1 Abnormal function and reorganization of presynaptic nanocomponents in experimental epilepsy: A multiphoton laser scanning confocal imaging and transmission electron microscopy study. Upreti C, Skinner F, Otero R, Thakker R, Rosas G, Partida C, Pacheco LF, Jones TA, Romanovicz D, Stanton PK and Garrido-Sanabria ER. 3 Meeting of the American Society for Nanomedicine, Rockville, MD, Nov 9-1...

Epilepsy is a common, disabling illness that is refractory to medical treatment in approximately one-third of patients, particularly among those with mesial temporal lobe epilepsy. While standard open mesial temporal resection is effective, achieving seizure freedom in most patients, efforts to develop safer, minimally invasive techniques have been underway for over half a century. Stereotactic...

OBJECTIVE Temporal intermittent rhythmic delta activity (TIRDA) is an EEG pattern characterized by sinusoidal trains of activity, ranging from 1 to 3.5 Hz, and well localized over the temporal regions. It is considered to be an indicator of temporal lobe epilepsy (TLE), but full agreement between different authors has still not been reached. The aim of this study was therefore to assess the rol...

Patients with temporal lobe epilepsy account for about 30 to 40% of the pharmacoresistant epilepsy and can be associated with impairments in multiple cognitive domains, including memory, language, executive function, intelligence and motor speed. Research studies investigating the generalized nature of cognitive impairment in temporal lobe epilepsy, which accounts for the commonest form of foca...

in this research, we have computationally investigated a mechanism for antiepileptic drugs (aed) and proposed bumetanide as a possible temporal lobe epilepsy (tle) treatment. experimentally it is difficult and devastating to determine the ionic mechanisms of depolarizing currents. it is obvious that chlorine and potassium transients are challenging to isolate pharmacologically and much γ-aminob...

Mesial temporal lobe epilepsy (MTLE) specifically consists of atrophy and gliosis within the limbic system and is the most frequent cause of medically intractable epilepsy in adults (2). Currently, the standard treatment for epilepsy is the use of anticonvulsants. Medically intractable cases may be treated with temporal lobectomy, consisting of removal of parts of the superior temporal gyrus, t...