The metabotropic glutamate receptor agonist (1S,3R)-1-aminocyclopentane-1,3 dicarboxylic acid (ACPD) at concentrations above 60 microM produced stereotypic oscillatory activity in CA3 pyramidal cells of rat hippocampal slices. This oscillatory activity consisted of trains of depolarizations with overriding action potentials. On average, individual trains lasted 7 sec and recurred at intervals o...

In the retina, neurotransmission from photoreceptors to ON-cone and rod bipolar cells is sign reversing and mediated by the metabotropic glutamate receptor mGluR6, which converts the light-evoked hyperpolarization of the photoreceptors into depolarization of ON bipolar cells. The Royal College of Surgeons (RCS) rat retina undergoes progressive photoreceptor loss due to a genetic defect in the p...

Dry-cured ham-derived dipeptides, generated along a dry-curing process, are of high importance since they play role in flavor development dry-cured ham. The objective this study was to analyze the residues less-studied metabotropic glutamate receptor 1 (mGluR1) implicated recognition umami ham dipeptides by molecular docking simulation using AutoDock Suite tool. AH, DA, DG, EE, ES, EV, and VG (...

Coopman, K., Bradley, S.J., Wilkinson, G.F. and Willars, G.B. G-protein coupling and glucagonlike peptide-1 signalling in recombinant cell-lines. 2 Focused Meeting Cell Signalling 16-17 April 2007. Poster Presentation. Bradley, S.J., Howes, C.M., Wood, M.D. and Challiss, R.A.J. Effects of Positive Allosteric Modulators of the mGlu5 Receptor on Oscillatory Patterns of Ca 2+ Signalling. Metabotro...

We used the single-cell culture preparation to study the role of activity in the development of glutamatergic synapses in vitro. Rat hippocampal cells grown in isolation on glial islands formed functional autaptic connections and continued to elaborate new synapses throughout the 2 week investigation, resulting in increases in both the evoked AMPA receptor (AMPAR) and NMDA receptor (NMDAR) comp...

BACKGROUND/AIMS Digestion of dietary protein elevates intraluminal concentrations of glutamate in the small intestine, some of which gain access to the enteric nervous system (ENS). Glutamate, in the central nervous system (CNS), is an excitatory neurotransmitter. A dogma that glutamatergic neurophysiology in the ENS recapitulates CNS glutamatergic function persists. We reassessed the premise t...

The metabotropic glutamate receptors have a wide range of modulatory functions in the central nervous system. They are among the most highly pursued drug targets, with relevance for several neurological diseases, and a number of allosteric modulators have entered clinical trials. However, so far this has not led to a marketed drug, largely because of the difficulties in achieving subtype-select...