Metabotropic glutamate receptors (mGluR)s are G-protein-coupled receptors that function as modulators of synaptic function and glutamate transmission. Post-synaptically localized subtype 5 mGlu5 receptors are co-localized with adenosine A2a, dopamine, and N-methyl-D-aspartate (NMDA) receptors and regulate local protein synthesis and messenger RNA (mRNA) translation at synapses, and are thus ide...

Synaptic plasticity in the cerebellar cortex is abolished and cerebellum-dependent motor learning is decreased in mice lacking a metabotropic glutamate receptor. Is the receptor involved in learning?

A family of proteins has been identified whose members, the Shanks, physically link two major receptor complexes at excitatory synapses - NMDA receptors and metabotropic glutamate receptors.

This paper introduces a computational model of integrated information in bidirectional neuron–astrocyte communication. Dynamical analysis and transfer process are studied when stimulation metabotropic glutamate is loaded into neuron astrocyte coupled model, respectively. The results show that the loading stimulus coupling strength cause neuronal hyper-excitation, which some way linked to epilep...

Group I metabotropic glutamate receptors (mGluRs) 1 and 5 frequently colocalize in the same neurons throughout the CNS. Because both receptors can couple to the same effector systems, the purpose of their cellular coexpression remains unclear. Here, we report that group I mGluR1 and mGluR5 have distinct functional roles in type II neurons of the rat globus pallidus (GP). Type II GP neurons form...

This research topic was aimed toward collecting the present knowledge of structure and function of sensory receptors in animal kingdom as well as the mechanisms of signal transduction and amplification. To translate external signals such as light, sound, smell, etc., into an appropriate intracellular signal, sensory receptors use either a fast, direct or a slow, indirect way. These qualitativel...

A number of studies suggest that OLGs (oligodendrocytes), the myelinating cells of the central nervous system, are also a source of trophic molecules, such as neurotrophins that may influence survival of proximate neurons. What is less clear is how the release of these molecules may be regulated. The present study investigated the effects of BDNF (brain-derived neurotrophic factor) derived from...

Cultured dorsal root ganglion neurons were voltage clamped at -90 mV to study the effects of intracellular application of nicotinamide adenine dinucleotide (betaNAD+), intracellular flash photolysis of caged 3',5'-cyclic guanosine monophosphate (cGMP), and metabotropic glutamate receptor activation. The activation of metabotropic glutamate receptors evoked inward Ca2+-dependent currents in most...