OBJECTIVES We investigated the histopathological effects of metamizole sodium (MS) on the sciatic nerve. MATERIALS AND METHODS This study was performed using 48 adult male Wistar albino rats. Ten groups were constituted with 6 rats in each group. MS injection into the sciatic nerve (group 1), MS injection into the muscle [group 3 (50 mg/kg, 0.4 ml) and group 5 (50 mg/kg, 0.8 ml)], MS injectio...

INTRODUCTION The term polypharmacy, meaning the concomitant use of multiple medications by one individual, has been widely reported in institutionalized or elderly patients. It can, however, occur in patients with chronic diseases, such as rheumatoid arthritis (RA). OBJECTIVE To quantify polypharmacy in a group of RA patients and to assess the risk of potential undesirable interactions betwee...

Introduction: Pain is a condition that the majority of critical care patients will possibly suffer at some point during their stay in intensive unti (ICU). In both medical and surgical ICU patients, incidence considerable pain still 50% or greater. Analgesic administration considered one most effective managements. While useful, it can cause detrimental effects if not used according to its indi...

BACKGROUND Since the publication of a major international case-control study on the risk of agranulocytosis associated with the use of medicines in the 1980s, many new drugs have been introduced in therapeutics. METHODS Seventeen units of hematology contribute to the case-control surveillance of agranulocytosis and aplastic anemia in Barcelona, Spain. After a follow-up of 78.73 million person...