Background: This study assessed the optimal timing of computed tomography for detection of metastatic disease in locoregional lymph nodes in patients with rectal cancer who have undergone chemoradiotherapy. Materials and Methods: This observational retrospective study was performed in a single institution. All patients with locally advanced rectal cancer treated with chemoradiotherapy, followed...

sentinel lymph node is the first regional lymph node that drains the lymph from the primary tumor. it is potentially the first nodeto receive the seeding of lymph‑borne metastatic cells. this study aimed to discuss lymphoscintigraphy procedural guidelines fordetection of sentinel node using tc‑phytate in isfahan, iran. moreover, the preliminary results of the first year’s clinical experience of...

To evaluate the value of lymph node status of primary tumors in predicting the prognosis of synchronous resectable metastatic colorectal cancer (mCRC). The characteristics of resectable mCRC are substantially different from other cancers, and the prognostic factors of resectable mCRC are still controversial. The data of 2007 patients with mCRC who received resection of the primary tumors and me...

PURPOSE There are various lymph node-based staging systems. Nevertheless, there is debate over the use of parameters such as the number of involved lymph nodes and the lymph node ratio. As a possible option, the distribution of metastatic lymph nodes may have a prognostic significance in rectal cancer. This study is designed to evaluate the impact of distribution-weighted nodal staging on oncol...

Axillary lymph node status is the most important prognostic factor in predicting disease outcome in women with breast cancer. A number of chromosomal aberrations in primary breast tumors have been correlated with lymph node status and clinical outcome, but chromosomal changes particular to metastatic lymph node tumors have not been well studied. DNA samples isolated from laser-microdissected pr...

Sentinel lymph node (SLN) status is the most accurate predictor of survival in melanoma patients with clinically negative regional nodes [1,2]. Until recently, metastatic S...

BACKGROUND Lymph node metastasis is a key event in the progression of breast cancer. Therefore it is important to understand the underlying mechanisms which facilitate regional lymph node metastatic progression. METHODOLOGY/PRINCIPAL FINDINGS We performed gene expression profiling of purified tumor cells from human breast tumor and lymph node metastasis. By microarray network analysis, we fou...

The aim of the study was to determine if age plays a role in the size of metastatic lymph nodes in elderly patients with squamous cell carcinoma of the head and neck (HNSCC). In 180 HNSCC patients with metastatic lymph nodes, largest metastatic lymph node (SMLN), diameter of metastatic deposit (DMD), and the ratio of non-metastatic lymphoid tissue to the size of largest metastatic lymph node (R...