The levels of two prostaglandins (prostaglandins E and F) have been determined in a series of murine mammary lesions ranging from preneoplastic, hyperplastic alveolar nodules to highly metastatic adenocarcinomas. A highly positive correlation was seen between high levels of prostaglandin E and high tumorigenicity and metastatic potential. In addition, spontaneous metastasis of two highly metast...

OBJECTIVES Results from the phase 3 Metastatic Pancreatic Adenocarcinoma Clinical Trial (MPACT) led to approval of nab-paclitaxel plus gemcitabine for first-line treatment of metastatic pancreatic cancer. The current analysis evaluated the effects of nab-paclitaxel plus gemcitabine versus gemcitabine on primary pancreatic and metastatic lesions. METHODS In this analysis of the previously desc...

UNLABELLED The aim of this study was to evaluate the diagnostic value of whole-body (18)F-FDG PET imaging in the differentiation of metastatic brain tumor from primary brain tumor and in the localization of the primary lesion in patients with metastatic brain tumor. METHODS The subjects consisted of 127 patients (77 men, 50 women; mean age +/- SD, 55 +/- 12 y) with brain masses that were susp...

abstractwe are reporting a 43-year-old female breast cancer case with a solitary metastatic adenocarcinoma in clivus. this patient with a stage ii (t1n1m0) breast cancer history has been followed for 7 years.  modified radical mastectomy (mrm) and 6 courses chemotherapy with cmf (cyclophosphamide, metotrexate, 5fu) regimen were done for her at the time of diagnosis. also, she took tamoxifen twe...

abstract: plasma cellmyeloma constitutes about 10% of all  hematologicmalignancies. metastatic cutaneous lesions without underlying bony involvement are rare and associated with advanced disease, poor prognosis and high tumor burden. igg is the most common subtype and igd is believed to have a more aggressive course.######

Bone metastases, present in 70% of patients with metastatic breast cancer, lead to skeletal disease, fractures and intense pain, which are all believed to be mediated by tumor cells. Engraftment of tumor cells is supposed to be preceded by changes in the target tissue to create a permissive microenvironment, the pre-metastatic niche, for the establishment of the metastatic foci. In bone metasta...

In accordance with extending survival periods of cancer patients, number of consecutively developing metastatic spinal tumor is also increasing. There have been improvements in the treatment results of metastatic spine tumor by virtue of the developments in diagnostic radiology, chemotherapy, adjuvant treatment, operative device and technique, discrete preoperative plan, and standardized operat...

Case report The patient was a multiparous, unmarried female, age 66 years. She presented with a history of sudden onset of varicose veins some months previously, followed by oedema of the ankles for 6 weeks. Eight years previously she was investigated extensively for post-menopausal vaginal bleeding, no cause being found at that time. At the same time a duodenal ulcer was discovered, and treate...

Meningioma is the commonest primary intracranial tumor in adults, with majority being benign. Malignant meningioma exceedingly rare and carries a poor prognosis because of its tendency for local recurrence distant metastasis. We present case 53 years old male anaplastic malignant meningioma, which recurred after excision radiotherapy later metastasised to pleura, bones brain. Keywords: Metastat...