background substance abuse or drug addiction is one of the most important health issues in every society, which can lead to physical and mental problems. objectives this study aimed to compare the efficacy of tramadol plus gabapentin versus methadone use in the treatment of opiate withdrawal. patients and methods consenting male subjects who fulfilled the dsm-4 criteria for opiate dependence sy...

how to cite this article: fayyazi a, khajeh a, bagheri m, ahmadi s. acute hydrocephaly following methadone intoxication in a child. iranian journal of childneurology 2012;6(1):35-38. infantile methadone intoxication has been on the rise since the usage of methadone in opioid detoxification programs. we report a 30-month-old child with encephalopathy and acute hydrocephaly following methadone in...

BACKGROUND One of the problems that addicts suffer from is decreased libido. Erectile dysfunction has been reported in men using opioids for treatment of heroin addiction. OBJECTIVE The study was performed to investigate the effects of morphine and detoxification with methadone as causes of sexual dysfunction in addiction. METHODS AND METHODS A total of 40 adult male rats (Wistar) were used...

TREATMENT of chronic pain in patients with a history of opioid addiction is difficult since tolerance to the opioid agonist effects may require extremely large opioid doses for pain control. Furthermore, insufficient pain control may be hard to discern from craving for more opioids. Although drug-free periods, also called “drug holiday,” can reestablish sensitivity to drugs used to treat Parkin...

OBJECTIVE Dysphoria and depression have been cited as side effects of the opioid antagonist naltrexone. We aimed to assess whether depressive symptoms are a clinically relevant side effect in a population receiving naltrexone as a treatment for opioid dependence. METHODS We carried out a randomized controlled, open-label trial comparing rapid opiate detoxification under anesthesia and naltrex...

RESUME. Despite the fact that opioids do not have direct nephrotoxicity, a significant overdose, or their combination with alcohol and other psychotropic substances, contributes to development of critical changes in many organs systems body, which leads, particular, acute kidney injury (AKI). Aim. Using comparative analysis Kaplan-Meier method, investigate survival rates patients opioid drug po...

Scientific interest in poisoning by synthetic opioids, particular Methadone, is due to a significant increase their number Kyiv over the past 15 years and fatal consequences. The Aim of Research. Is identify causes associated with methadone determine measures prevent them. Materials Methods. A retrospective analysis medical data 1340 patients Methadone who were treated at Toxicology Center peri...