Since the approval of buprenorphine for treatment of opioid use disorder (OUD) in 2002, it has become increasingly likely that some individuals with OUD will have been treated with both buprenorphine and methadone at different points in time. However, this emergent group of patients has not been well described. We completed a retrospective cohort study of individuals at the Cincinnati Veterans ...

This study examines the pharmacokinetic/pharmacodynamic interactions between (1) lopinavir-ritonavir (L/R), a fixed combination of protease inhibitors used for the treatment of HIV disease, and (2) ritonavir alone at the same dosage as that in the L/R formulation, with methadone, an opiate frequently used in substance abuse pharmacotherapy for opioid (heroin)-dependent injection drug users, man...

of prescribing injectable heroin and methadone to opiate-dependent drug users: associated health gains and harm reductions. Active heroin injectors' perceptions and use of methadone maintenance treatment: cynical performance or self-prescribed risk reduction? Substance It takes your heart: the image of methadone maintenance in the addict world and its effects on recruitment into treatment. Opia...

We assessed the prevalence of neonatal abstinence syndrome (NAS) and fetal growth outcomes in neonates exposed to methadone compared buprenorphine utero. Three authors titles abstracts all potentially eligible studies. The selection criteria were randomized controlled trials observational cohort studies from January 2000 2020 which indexed reported original data for occurrence NAS pregnant peop...

Methadone maintenance has been evaluated since its development in 1964 as a medical response to the post-World War II heroin epidemic in New York City. The findings of major early studies have been consistent. Methadone maintenance reduces and/or eliminates the use of heroin, reduces the death rates and criminality associated with heroin use, and allows patients to improve their health and soci...

Objectives: Methamphetamine (MA) dependence is a new health problem among Iranian female methadone patients. In recent years, the Matrix Model (a sixteen-week psychosocial treatment) has been provided for treating MA dependence. However, the problems associated with this treatment in methadone services are not clear. Methods: A qualitative study was conducted to explore the problems associated...

INTRODUCTION AND AIMS The aim of this study was to compare the mortality associated with oral naltrexone, methadone and buprenorphine in opioid dependence treatment, employing a retrospective data analysis using coronial and prescription data. DESIGN AND METHODS The number of deaths were identified through national coronial data and number of treatment recipients were estimated from 2000 to 2...

results patients reported that their use of methamphetamine was motivated by methadone’s side effects and encouraged by family and friends who promoted methamphetamine use to assuage the side effects of methadone in the early stages of treatment before the appearance of methadone maintenance therapy’s effects on their life. patients and methods to gain a better understanding of patients’ motiva...