Methamphetamine abuse has become a significant problem in the United States with recent surveys reporting that nearly 10 million Americans have tried methamphetamine at least once. Methamphetamine is a stimulant drug that causes the release of monoamine neurotransmitters. Among its most deleterious effects are its ability to produce tachycardia, hypertension, and ischemia. However, it also has ...

Lobeline is currently being evaluated in clinical trials as a methamphetamine abuse treatment. Lobeline interacts with nicotinic receptor subtypes, dopamine transporters (DATs), and vesicular monoamine transporters (VMAT2s). Methamphetamine inhibits VMAT2 and promotes dopamine (DA) release from synaptic vesicles, resulting ultimately in increased extracellular DA. The present study generated st...

Acceptance and Commitment Therapy (ACT) incorporates developments in behavior therapy, holds promise but has not been evaluated for methamphetamine use disorders. The objective of this study was to test whether ACT would increase treatment attendance and reduce methamphetamine use and related harms compared to cognitive behavior therapy (CBT). One hundred and four treatment-seeking adults with ...

OBJECTIVE Proton magnetic resonance spectroscopy (1H-MRS) showed decreased neuronal marker N-acetylaspartate and increased glial marker myo-inositol in subjects with chronic methamphetamine use and in subjects infected with HIV. The authors sought to determine whether HIV and a history of chronic methamphetamine use might have additive or interactive effects on brain metabolite abnormalities. ...

Citation: Loftis JM (2015) Commentary: Methamphetamine mediates immune dysregulation in a murine model of chronic viral infection. A commentary on Methamphetamine mediates immune dysregulation in a murine model of chronic viral infection The recent article by Sriram et al. (2015) is one of the first studies to evaluate the effects of methamphetamine on peripheral T cell responses, in the contex...

ABSTRACT Illicit drug abuse presents pervasive adverse consequences for human societies around the world. consumption also plays an unexpected role in contamination of aquatic ecosystems that receive wastewater discharges. Here, we show methamphetamine, considered as one most important global health threats, causes addiction and behavior alteration brown trout Salmo trutta at environmentally re...

The use of the recreational drug crystal methamphetamine among younger homosexual men is expanding, and with it, unsafe sex behaviors that increase the transmission of human immunodeficiency virus (HIV). This article reviews available literature on the medical and psychiatric morbidities associated with methamphetamine abuse in HIV-infected patients. Medical complications include hypertension, ...

abstract         background and objective: methamphetamine has strong stimulating effects on various systems of the human body. the aim of this study was to evaluate the hematological and biochemical parameters in methamphetamine addicts and to compare them with healthyindividuals.      methods: this is a retrospective case-control study that was conducted in 1390-91 in ibn sina hospital in shi...