OBJECTIVE To examine the dynamics of oxidative stress in patients with hyperthyroidism before and during the treatment with methimazole using the measurement of conjugated dienes, malondialdehyde, and Schiff bases in blood serum. METHODS In eight female patients with diagnosed Graves disease and 8 healthy control subjects (7 females and one male) several parameters of oxidative stress (the le...

Transdermal methimazole is suggested as an alternative to oral therapy for hyperthyroid cats that are difficult to pill. However, no information on long-term management with this treatment is available. Our objective was therefore to retrospectively evaluate the efficacy and safety of long-term transdermal methimazole treatment in hyperthyroid cats. Sixty cats with newly diagnosed hyperthyroidi...

This report demonstrates the ability of a microfluidic device to maintain human Graves' disease tissue enabling isolation and characterisation specific exosomes. (n = 7) non-Graves’ (Hashimoto's thyroiditis, n 3; follicular adenoma, 1) was incubated in for 6 days ± dexamethasone or methimazole effluent analysed size concentration extracellular vesicles (EV) using nanoparticle tracking analysis....

A 46-year-old woman with a history of Graves' disease presented with the chief complaints of appetite loss, weight loss, fatigue, nausea, and sweating. She was diagnosed with diabetic ketoacidosis (DKA), thyroid storm, and influenza A. She was treated with an intravenous insulin drip, intravenous fluid therapy, intravenous hydrocortisone, oral potassium iodine, and oral methimazole. As methimaz...

the regioselective ring opening of styrene oxide using elemental iodine and bromine in the presence of disulfides as new catalysts was studied. the conductivity titration and uv spectroscopy were used to study the interaction of iodine with these catalysts. the results indicate that disulfide 11 is efficient in polyiodide formation, and can catalyze this reaction in excellent yield and high reg...

The response to methimazole and propylthiouracil was evaluated in patients with toxic goiter residing in Tehran, an area of iodine deficiency. Treatment with methimazole, 10 mg twice daily, in 15 patients decreased FT4I from 22.7±6.8 to 12.1±2.5, 10.8±2.8 and 6.0±4.3, 8, 14 and  28 days after treatment respectively. Corresponding FT 3I values were 415±90, 196±36, 162±44 and 117±4 6.At  28 day...

The glucosinolate autolysis products of crushed seeds of DesclIrainia sophia L. (khakeshi) and Brassica napus L. (shelghem) were administered orally to rats in doses representing 8,16 and 32 gm seeds/kg body weight/day at intervals of 10, 20 and sometimes 30 days. Serum T3 and T4 concentrations were reduced in 10 day•autolysate treated animals in a similar fashion to that found with methim...

introduction thyroid storm is a rare complication of graves' disease that can carry a poor prognosis. in order to prevent major complications, thyroid storm must be quickly identified in patients and treatment must be promptly implemented. medical treatment is usually initiated with antithyroid medications, such as propylthiouracil (ptu), methimazole, and beta-blockers. however, some patients m...