نتایج جستجو برای: methylxanthines
تعداد نتایج: 350 فیلتر نتایج به سال:
The immunomodulating capacity of the methylxanthine A802715 (5-hydroxy-5-methyl)hexyl-3-methyl-7-propylxanthin) was investigated in various murine models of endotoxemia and compared with that of the chemically related reference compound pentoxifylline. At a dose of 180 mg/kg both compounds protected mice against a lethal shock dose of lipopolysaccharide (LPS) (5 mg/kg) in nonsensitized mice and...
1. A form of skeletal muscle fatigue was examined with isolated animal and human muscle preparations. The possibility that methylxanthines could overcome this was investigated. 2. Prolonged contractile activity resulted in a long-lasting impairment of force generation at low frequencies of stimulation at times when the force at higher frequencies had substantially recovered. This was seen with ...
Methylxanthines elicit from otherwise untreated rats several of the behavioural signs seen in the morphine abstinence syndrome (MAS). Heroin readily suppresses the signs elicited by methylxanthines, and naloxone increases their intensity and elicits other signs, such as jumping, to produce a behavioural pattern scarcely distinguishable from the MAS (Collier, Francis, Henderson & Schneider, 1974...
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