نتایج جستجو برای: mexab
تعداد نتایج: 200 فیلتر نتایج به سال:
BACKGROUND Small colony variants (SCVs) are slow-growing bacteria, which often show increased resistance to antibiotics and cause latent or recurrent infections. It is therefore important to understand the mechanisms at the basis of this phenotypic switch. METHODOLOGY/PRINCIPAL FINDINGS One SCV (termed PAO-SCV) was isolated, showing high resistance to gentamicin and to the cephalosporine cefo...
Drug efflux systems contribute to the intrinsic resistance of Pseudomonas aeruginosa to many antibiotics and biocides and hamper research focused on the discovery and development of new antimicrobial agents targeted against this important opportunistic pathogen. Using a P. aeruginosa PAO1 derivative bearing deletions of opmH, encoding an outer membrane channel for efflux substrates, and four ef...
Pseudomonas aeruginosa is equipped with the Sec and Tat protein secretion systems, which translocate the xenobiotic transporter MexAB-OprM and the pathogenic factor phospholipase C (PlcH), respectively. When the signal sequence of MexA was replaced with that of PlcH, the hybrid protein was successfully expressed and recovered from the periplasmic fraction, suggesting that the hybrid protein had...
Pseudomonas aeruginosa, one of the majority common opportunistic infections, has become a public health concern, exhibiting intrinsic and acquired resistance to wide range antimicrobials. The present work aimed study correlation between P. aeruginosa efflux pump mexAB-oprM genes antibiotic different types antibiotics. All 79 isolates were screened by chromogenic agar, which was used as selectiv...
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