A 53 year old man with Felty's syndrome presented with abdominal pain and fever. He underwent a laparotomy after starting broad spectrum antibiotics. An intestinal biopsy showed skip ulcers with fungal hyphae. Peritoneal exudates grew Candida albicans. He was started on intravenous fluconazole and then switched to liposomal amphotericin to which he showed a good clinical response. After one mon...

In the course of a survey of the effect of injection of extracts and suspensions of normal tissues upon body temperature in rabbits (1), it was found that the intravenous inoculation of suspensions of whole polymorphonuclear leukocytes, extracts from these cells, or supernatant fluids obtained from sterile peritoneal exudates containing granulocytes produced febrile responses in normal rabbits....

The present investigation summarizes the effect of Linum usitatissimum fixed oil against different phases of acute inflammatory reaction, namely, protein exudation, peritoneal capillary permeability, and leukocyte migration. The fixed oil exhibited dose-dependent inhibition of protein exudation vascular permeability, comparable to standard aspirin. The oil also inhibited the leukocyte migration...

1. When peritoneal exudates are produced in the rabbit by the injection of a large volume of isotonic saline, nearly all the cells in the exudate are polymorphonuclear leucocytes, and the number contained in a single exudate may exceed the entire number originally present in the circulation. 2. The migration of polymorphonuclear leucocytes from the blood stream into the exudate is followed by a...

Observations on mouse monocytes, maintained in cell culture and inoculated with Histoplasma capsulatum, have been previously reported (Howard, 1959). H. capsulatum differs from other fungi pathogenic for man in that it is primarily a parasite of cells of the reticulo-endothelial system. Thus the fungus was ideally suited to preliminary studies on the usefulness of tissue culture techniques for ...

BACKGROUND Interferon γ (IFN-γ) increases the expression of multiple genes and responses; however, the mechanisms by which IFN-γ downmodulates cellular responses is not well understood. In this study, the repression of CCL3 and CCL4 by IFN-γ and nitric oxide synthase 2 (NOS2) in macrophages and upon Salmonella typhimurium infection of mice was investigated. METHODS Small molecule regulators a...

YSOZYME IN BLOOD, especially in white cells, has beemi demonstrated by several investigators. In the rabbit amid cat, Barnes’ found very little activity in lymphocytes obtained by thoracic duct cannulatiomi amid a large amount of activity in polymorphonuclear and mononuclear cells from peritoneal exudates. Sammons’ observed that lysozyme activity in exudates varied with the number of pus cells....

Tritiated thymidine-labeling data in individual and parabiotic rats showed that macrophages in peritoneal exudates were derived from cells in the blood which were the progeny of rapidly and continuously proliferating precursors. The characteristics of this population identify them with free macrophages studied in other sites; similarly, they can be obtained from transfused bone marrow. Cells in...