Delivery systems with a solid dispersed phase can be produced in a melt emulsification process. For this, dispersed particles are melted, disrupted, and crystallized in a liquid continuous phase (melt emulsification). Different to bulk crystallization, droplets in oil-in-water emulsions show individual crystallization behavior, which differs from droplet to droplet. Therefore, emulsion droplets...

the purpose of this study is to produce an oil-in-water nano-emulsion by ultrasonication. casein combined with inulin used as continuous phase, while dispersed phase consisted of fish oil. the size of the nano-emulsion and the ph of nano-emulsion were characterized. ultrasound has been used for preparing emulsion by 24 khz intensity for 120 seconds. prepared nano-emulsion was investigated by pa...

double emulsion solvent evaporation technique is one of the most attractive methods used to prepare micro and nanoparticles in pharmaceutical areas of interest, but because of the effects of many formulation factors on the size and release behavior of the fabricated particles, optimization of the formulation factors is needed. in this study various parameters including technical and composition...

Efficient mixing strategies in a fluid involve generation of multi-scale flows which are strongly suppressed in highly viscous systems. In this work, we report a novel form of multi-scale flow, driven by an external electric field, in a highly viscous (η∼ 1 Pa s) oil-in-oil emulsion system consisting of micron-size droplets. This electro-hydrodynamic flow leads to dynamical organization at spat...

there are numerous problems for using essential oil due to its low solubility in water, high vapor pressure and chemical and physical instability. use of nano-emulsions is a good idea for decreasing side effect of the essential oils and enhance their efficiency as well as delivery to hot spot. in addition, nano-emulsion system make smaller size particles and increase stability and shelf-life of...

Efavirenz is a drug with an absorption window. Its oral bioavailability is 40-50%. The aim of this work was to formulate solid self-emulsifying drug delivery system to improve the solubility and bioavailability of efavirenz. Solubility of Efavirenz was determined in various vehicles like oils, surfactants and co surfactants. Which, upon dilution with aqueous media, spontaneously form fine oil i...

Esterification of starch was carried out to expand the usefulness of starch for a myriad of industrial applications. Lipase B from Candida antarctica, immobilized on macroporous acrylic resin (Novozym 435), was used for starch esterification in two reaction systems: micro-solvent system and solvent-free system. The esterification of corn starch with palmitic acid in the solvent-free system and ...

Micro-segmented flow (e.g. in microfluidic channels, capillaries or a length of tubing) has become a promising technique in modern biology. Compared to conventional formats such as microtiter plates, sample volumes can be reduced about 1000-fold, thus allowing a massive reduction of assay costs and the use of samples available in low quantities, only (e.g. primary cells). Furthermore, assays ca...

Continuous crystallization of lipid nanoparticles, carrying bioactive compounds, is employed as model system for food products to demonstrate benefits, application possibilities and challenges of microscale process engineering. It could be shown, that high and well-defined cooling rates (up to 104 times higher compared to the standard batch process) can be achieved by using a micro heat exchang...

Here we present the experimental findings of research into integral characteristics secondary droplets produced from micro-explosive fragmentation two types initial droplets. Both are based on water and tetradecane: an emulsion droplet a two-component immiscible with as core tetradecane envelope. We study threshold (critical) conditions for micro-explosion substrate heated up to 550 °C. In cour...