The purpose of this research was to study the neutralization efficacy of a universal neutralizer proposed by the CTPA on a range of antimicrobial agents and its potential toxicity for microorganisms that are used for antimicrobial preservation testing. Several types of antimicrobial agents including a mixture of methylisothiazolinone and its 5-chloro derivative, dimethylol dimethyl hydantoin, Q...

background and objectives: sodium nitrite and potassium nitrite have been traditionally used for inhibition of clostridium botulinum and also as an agent to stabilize the color of meat products; however, usage of these additives at high levels could lead to toxicity and cancer originating from the formation of nitrosamines. nowadays, application of natural preservatives in order to reduce the n...

An actinomycete strain No. Q996-17 produced a novel compound, epoxomicin, which exhibited in vivo antitumor activity against B16 melanoma. Structural studies indicated that it is a new member of the epoxy-beta-aminoketone group, and is closely related to eponemycin.

Microbial biotransformation is a great model system to produce drugs and biologically active compounds. In this study, we elucidated the fermentation and production of an anti-cancer agent from a microbial process for regiospecific hydroxylation of resveratrol. Among the strains examined, a potent strain showed high regiospecific hydroxylation activity to produce piceatannol. In a 5 L (w/v 3 L)...

9 Recombinant proteins are often purified from microbial lysates containing high concentrations of nucleic acids. Pre-purification 10 steps such as nuclease addition or precipitation with polyethyleneimine or ammonium sulfate are normally required to reduce 11 viscosity and to eliminate competing polyanions before anion exchange chromatography. We report that small polycationic 12 compaction ag...

Biological weapons are assigned high priority in homeland security, defence, counterproliferation, nonproliferation, intelligence, and counterterrorist programmes. In order to strengthen active defense against development and use of these weapons, several comprehensive technological and forensic capabilities have been developed world over for investigative, intelligence, prosecutive, diplomatic...

Chemical modification of the naturally occurring phlorophenone antimicrobial agent caespitin is described. These modifications include variations in the phenone side chain, substitution with prenyl, allyl, and benzyl in the 4-position of the phlorophenone nucleus, and ring cyclizations via etherification to give furan and chroman compounds. Several of these derivatives show enhanced in vitro po...

We designed this review to describe a compilation of studies enlighten the concepts plant–microbe interactions, adopted protocols in smart crop farming, and biodiversity reaffirm sustainable agriculture. The ever-increasing use agrochemicals boost production has created health hazards humans environment. Microbes can bring up hidden strength plants, augmenting disease resistance yield, hereafte...