Drug addiction has developed to a social illness. Changes in glutamate transmission have been recorded by the repeated administration of addictive drugs into VTA. In this investigation, In vivo microdialysis was used to study the effects of morphine on glutamate release from the ventral tegmentum area (VTA) in freely moving rats. Rats were anesthetized with chloral hydrate (350 mg/kg, i.p.) and...

In this paper the novel method of calibration of glucose amperometric type sensor implemented in an integrated microdialysis based micro system is presented. This method consists in evaluation of the charge, resulting from the glucose consumption in the enzymatic reaction, transferred to the electrode under stop-flow conditions.

Analytical systems integrating in vivo microdialysis sampling with enzyme-based electrochemical biosensor detection have been increasingly accepted to be a new technique for continuous and on-line monitoring of biologically important species. Extensive interests in such integrated on-line analytical systems have suggested that these systems are very useful for physiological and pathological inv...

Microdialysis is a technique for sampling the chemistry of the interstitial fluid of tissues and organs in animal and man. It is minimally invasive and simple to perform in a clinical setting. Although microdialysis samples essentially all small molecular substances present in the interstitial fluid the use of microdialysis in neurointensive care has focused on markers of ischemia and cell dama...

Abstract Background ‘Choke vessels’ are thought to dilate in the first 72 h when blood flow an area is disrupted. This study used ‘high cut-off’ microdialysis catheters clinical research investigate factors mediating circulatory change within free flaps. Methods Six patients undergoing DIEP flap breast reconstruction each had three catheters, with a membrane modification allowing molecules as l...

Abstract: From anesthetized rats in the 90s to conscious wild-type or knockout mice today, intracerebral in vivo microdialysis provided important information about the brain mechanism of action of psychotropic drugs such as antidepressants. The principle of microdialysis technique is based on the balance between the release of neurotransmitters (e.g., serotonin 5-HT, norepinephrine, dopamine) a...