Allopurinol is a relatively water-insoluble drug and, consequently, its efficacy was frequently limited by the dissolution or solubility phenomena. The purpose of this study to improve solid-state properties and behavior allopurinol via supercritical antisolvent (SAS) process using CO2 as an antisolvent. effects operating parameters: temperature (35–55 °C), pressure (80–100 bar), solution conce...

Panax notoginseng (PN) has become the most widely used dietary supplement and herbal in Asian countries. The effect of micronization on PN is not entirely clear. aim this study was to investigate effects particle size powder (PNP) potential improve bioavailability. results showed that reduction significantly changed saponins (PNS) vitro dissolution vivo pharmacokinetics. ranges from 60 214 μm. ...