BACKGROUND Few studies are available evaluating the impact of rapid-acting insulin analogues on long-term diabetes outcomes. Our aim was to compare the use of rapid-acting insulin analogues versus human regular insulin in relation to the occurrence of diabetic complications in a cohort of diabetic patients through the analysis of administrative databases. METHODS A population-based cohort stu...

AIM Evaluate the effect of lipopenic and hypotensive treatment on homocysteine levels. METHODS We recruited 145 type 2 diabetics and 130 control subjects. Thirty-seven diabetics had no complications, 54 had microvascular complications and 54 had macrovascular complications. We determined the parameters homocysteine of lipid, vitamin B12, triglycerides, and folates for all subjects. Associated...

conclusions anemia is a common complication of dm and is associated with duration of disease and microvascular complications. results a total of 93 patients (30.4%) had anemia including 46 (15.1%) with normochromic normocytic, 44 (14.4%) with hyperchromic microcytic, and 3 (1%) with hyperchromic macrocytic anemias. there was a positive correlation between duration of dm and anemia. microvascula...

BACKGROUND The Korean National Diabetes Program (KNDP) cohort study is performing an ongoing large-scale prospective multicenter investigation to discover the pathogenesis of type 2 diabetes in Korean patients. This study was performed to examine the prevalence of chronic complications in patients with type 2 diabetes among those registered in the KNDP cohort within the past 4 years. METHODS ...

Multiple and complex pathways promote the deleterious effects of hyperglycemia in diabetes, ultimately leading to micro- and macrovascular disease. Some of the known mechanisms in diabetic vascular disease may explain the initiation of the "metabolic memory", but fall short if long periods of time are involved.Vascular research has been prolific in the past in finding links between microvascula...

This study estimates health utilities (HU) in Sweden for a range of type 2 diabetes-related complications using EQ-5D and two alternative tariffs (UK and Swedish) from 1757 patients with type 2 diabetes from the Swedish National Diabetes Register (NDR). Ordinary least squares were used for statistical analysis. Lower HU was found for female gender, younger age at diagnosis, higher BMI, and hist...

Lipoprotein (a) is known to have thrombotic and atherogenic features. Considering thrombotic and atherogenic features of Lp (a), the present study was planned to investigate the significance of lipoprotein (a) as a risk factor for the development of microvascular and macrovascular complications of diabetes. A total of 71 subjects were included in the study. In order to assess nephropathy, 24-ho...

Diabetes mellitus (DM) is a crucial metabolic disease that leads to severe disorders. These include macrovascular complications such as myocardial infarction, stroke, and peripheral artery disease and microvascular complications including diabetic nephropathy, neuropathy, and retinopathy. Diabetes mellitus, along with its associated organ pathologies, is one of the key problems in today's medic...

Diabetes Mellitus is a serious global health problem. Both type 1 and type 2 diabetes markedly increase the risk of microvascular and macrovascular complications. Chronic complications of diabetes (retinopathy, nephropathy, neuropathy, and diabetes accelerated arteriosclerosis) represent a major medical and economical concern. Several pathogenic mechanisms were proposed to be responsible for th...

The prevalence of diabetes in Korea has increased six- to sevenfold over the past 40 years with its complications becoming major causes of morbidity and mortality. The rate of death among patients with diabetes is about twice as high as that among persons without diabetes and the most common cause of death is cardiovascular disease (30.6%). Despite the seriousness of diabetic complications, 30 ...