CONTEXT Migraine is considered to be an episodic condition with no long-term consequences. However, recent studies suggest that migraine attacks may be associated with pathologic changes in the brain, particularly in the cerebellum. OBJECTIVE To determine whether individuals not reporting headache compared with individuals reporting migraine symptoms, particularly aura, in midlife are at incr...

Migraine headaches are common in children and adolescents, with a wide spectrum of clinical forms. The most frequent pattern in children is migraine without aura, characterized by attacks of frontal, pounding, nauseating headache lasting 1 to 72 hours. The spectrum of migraine with aura includes migraine with typical aura, hemiplegic migraine, and basilar-type migraine, all of which may manifes...

Previous studies suggest an abnormal cerebral cortical energy metabolism in migraineurs. If causally related to the pathophysiology of migraine, these abnormalities might show a dose-response relationship with the duration and severity of aura symptoms. While such a trend has been suggested in phosphorus spectroscopy (31P-MRS) studies, it has not been considered in proton spectroscopy (1H-MRS) ...

Background: Menstrual Migraine (MM) is a subgroup of migraine headache that affect the quality of life of patients in menstrual age. Iron Deficiency Anemia (IDA) is the most common cause of anemia, especially in women of reproductive age. Objectives: To determine the association of iron deficiency anemia with menstrual migraine. Materials and Methods: This descriptive-analytic study was c...

OBJECTIVE To confirm syntaxin 1A as a risk factor for migraine, given that syntaxin 1A interacts with several factors in migraine pathophysiology. DESIGN Case-control approach. SETTING An outpatient clinic. PARTICIPANTS In a sample of 188 migraineurs (111 without aura and 77 with aura) and 287 migraine-free controls, 3 tagging SNPs of STX1A (rs3793243, rs941298, and rs6951030) were analyz...

OBJECTIVE To assess the efficacy and safety of cinnarizine for the prophylaxis of migraine associated vertigo in the vestibular migraine and migraine with brainstem aura. BACKGROUND Vestibular migraine and migraine with brainstem aura are two principal clinical syndromes that frequently are associated with vertigo. Since cinnarizine is a well-tolerated calcium channel blocker which has accept...

Objectives At the conclusion of this program, participants should be able to: 1. Identify the typical features of migraine aura. 2. Describe the pathophysiologic mechanisms behind migraine aura. 3. Correlate the physiology of cortical spreading depression to the clinical phenomena of migraine aura. 1. Migraine aura is associated with which of the following conditions: a. Cortical spreading depr...

background: the sporadic type of hemiplegic migraine (hm) is sometimes observed among migrainous patients (mp) and mimics ischemic strokes. methods: in an evaluation of two-hundred consecutive adult mp in the mackenzie headache clinic, canada during 2004 , 9% of the patients met the criteria established by the international headache society for sporadic hm. female to male sex ratio, family hist...

Migraine is the most common form of headache disorder globally. The etiology of migraine is multifactorial, with genetic components and environmental interactions considered to be the main causal factors. Some researchers postulate that deficits in mitochondrial energy reserves can cause migraine or an increase in homocysteine levels can lead to migraine attacks; therefore, vitamins could play ...