The FLEET computer [1] is a new architecture designed from the ground up with parallelism in mind, providing the programmer with direct control over data movement and concurrency. Since FLEET is a completely new architecture, programming for it can be quite challenging. The machine is inherently parallel, so sequential programming techniques do not directly translate to it. The MIPS to FLEET tr...

In animal cells, myo-inositol is an important regulatory molecule in several physiological and biochemical processes, including signal transduction and membrane biogenesis. However, the fundamental biological functions of myo-inositol are still far from clear in plants. Here, we report the genetic characterization of three Arabidopsis thaliana genes encoding D-myo-inositol-3-phosphate synthase ...

Polymyxins are cyclic lipopeptide antibiotics that serve as a last line of defense against Gram-negative bacterial superbugs. However, the extensive accumulation of polymyxins in renal tubular cells can lead to nephrotoxicity, which is the major dose-limiting factor in clinical use. In order to gain further insights into the mechanism of polymyxin-induced nephrotoxicity, we have rationally desi...

The MIPS group (Martinsried Institute for Protein Sequences) at the Max-Planck-Institute for Biochemistry, Martinsried near Munich, Germany, collects, processes and distributes protein sequence data within the framework of the tripartite association of the PIR-International Protein Sequence Database (,). MIPS contributes nearly 50% of the data input to the PIR-International Protein Sequence Dat...

Myo-Inositol Phosphate Synthase (MIPS; EC 5.5.1.4) catalyses the first committed step in inositol biosynthesis. The enzyme converts D-glucose 6-phosphate, an intermediate of the glycolytic pathway, to myo-inositol phosphate (Ins phosphate), which is subsequently converted to myo-inositol by the action of inositol monophosphatase [3]. It has been demonstrated that MIPS is a key enzyme during the...

Molecular imprinting is a mature and appealing technology to obtain highly selective recognition sites created within polymeric network, having other important features such as robustness cost effectiveness. The applications of molecularly imprinted polymers (MIPs) are vast, but there continuous particular interest in their integration into sensing devices. MIPs possess remarkable properties te...