BACKGROUND: Interest in minimally invasive surgery (MIS) of the spine has driven the development of new and innovative techniques to treat an ever wider range of spinal disorders. Despite these new advances, spine surgeons have been slow in adopting MIS into their clinical practice. This study aims to provide a better understanding of the factors that have led to limited incorporation of these ...

Given a finite set V , and integers k ≥ 1 and r ≥ 0, denote by A(k, r) the class of hypergraphs A ⊆ 2 with (k, r)-bounded intersections, i.e. in which the intersection of any k distinct hyperedges has size at most r. We consider the problem MIS(A, I): given a hypergraph A and a subfamily I ⊆ I(A), of its maximal independent sets (MIS) I(A), either extend this subfamily by constructing a new MIS...

-Concentrations of the hypoxic cell radiosensitizer misonidazole (MIS) and its 0 -demethylated metabolite Ro 05 -9963 were determined in plasma (or blood), brain and tumour after injection of I g/kg MIS i.p. to control mice or mice pretreated with 4-6 daily injections of phenobarbitone or phenytoin. Analysis was by highperformance liquid chromatography (HPLC). Phenobarbitone and phenytoin did n...

The MIS discipline faces the need to periodically re-establish its relevance to both academics and practitioners. Evolving technology forces our discipline to change at a rate far exceeding that of other business disciplines. In the workplace, rapidly evolving IT management issues and technologies have led corporations to manage technical employees differently than other employees. In academia,...

EXECUTIVE SUMMARY In the beginning of 1999, the CIO of a Portuguese company in the automobile industry was debating with himself whether to abandon or to continue supporting the MIS his company had been using for years. This MIS had been supporting the company’s production processes and the procurement of resources for these processes. However, in spite of the fact that the MIS system had been ...

müllerian inhibiting substance (miS), also known as anti-müllerian hormone (amh), is a glycoprotein belonging to the transforming growth factor ß superfamily. In Japanese flounder (Paralichthys olivaceus), a teleost fish that has XX(female)/XY(male) sex determination system, mis mRNA is expressed in the somatic cells of the gonads during gonadal sex differentiation. However, the mechanism of tr...

Multiple invasions (MIs) or infections, i.e. those by more than 1 parasite in the same erythrocyte, could be the result of parasite density or, alternatively, to parasite-related factors or host-related factors. According to the last possibility, to our knowledge, only 3 laboratory studies of malaria have found an increase in the occurrence of MIs when antibodies to parasite antigens were prese...

Mullerian Inhibiting Substance (MIS), a 140-kDa homodimer glycoprotein member of the TGF-beta superfamily of biological-response modifiers, causes regression of the Mullerian ducts in developing male embryos. MIS also can induce growth arrest and apoptosis in ovarian and cervical cancer cell lines. The embryonic progenitor of the ovarian and cervical epithelium is the coelomic epithelium, the s...

Since Mullerian Inhibiting Substance (MIS) causes regression of the Mullerian duct, the anlagen of the uterus, vagina, and fallopian tube, we expected and have previously observed that purified recombinant human MIS causes regression of gynecological tumors. However, recent experiments indicating that neural crest derivatives might be responsive to MIS prompted study of a group of human ocular ...