Phellodendrine is a Phellodendri Cortex-derived isoquinoline alkaloids, has been shown to have various activities, especially hypoglycemic effect in mice, predicting its medicinal value on diabetes mellitus. To further understand the pharmacological of phellodendrine mellitus, network techniques used elaborate involved mechanisms. 84 common target molecules were screened, based chemical structu...

Ras and Raf-kinase interact through the Ras-binding (RBD) cysteine-rich domains (CRD) of Raf to signal mitogen-activated protein kinase pathway, yet molecular mechanism leading activation has remained elusive. We present 2.8 Å crystal structure HRas–CRaf-RBD_CRD complex showing Ras–Raf interface as a continuous surface on Ras, seen in KRas–CRaf-RBD_CRD structure. In dynamics simulations dimer m...