Taro MATSUO, Hiroshi SHIBAI, and Mitsunobu KAWADA Graduate School of Science, Nagoya University, Furo-cho, Chikusa-ku, Nagoya 464-8602 [email protected], [email protected], [email protected] Makoto HATTORI and Izumi S. OHTA Graduate School of Science, Tohoku University, 6-3 Aoba, Aramaki, Aoba-ku, Sendai 980-8578 [email protected], [email protected] and Hirosh...

The 7-(4-aminomethyl-1H-1,2,3-triazol-1-yl) analogue of kabiramide C (5) was synthesized by using the Mitsunobu reaction and 1,3-dipolar cycloaddition. This compound and the intermediate compounds 2 and 4 were shown to bind tightly to G-actin in a 1:1 complex and exhibited the same degree of cytotoxicity as 1. Compound 5 serves as a key intermediate for the synthesis of actin-directed optical p...

This study describes an attempt to develop a synthetic route using theoretical calculations, i.e., in silico synthesis route development. The KOSP program created four potential synthetic routes for generating 2,6-dimethylchroman-4-one. In silico screening of these four synthetic routes was then performed. In silico screening involves theoretical analysis of synthetic routes prior to actual exp...

Abstract Two unnatural regioisomeric glycosylated Gilvocarcin analogues were proposed as model compounds to study the origin behind biosynthetic development of Gilvocarcins, a class bioactive C ‐aryl glycoside natural products. More specifically, origins O ‐ ‐glycoside migration in evolution biosynthesis for these classes Angucycline antibiotic For stability reasons 5a‐carbasugar motif was used...

A seven-step synthetic route has been developed to access the labile C-3 unsubstituted 5-phenylthiomorpholinone system for first time. The key step involved nucleophilic ring opening of Boc-phenylmorpholinone give corresponding methyl ester. sulfur introduction was accomplished through a Mitsunobu reaction yield thioacetate, which then hydrolysed provide thiol acid. Cyclization acid achieved us...