Cumulative relative survival curves for many cancers reach a plateau several years after diagnosis, indicating that the cancer survivor group has reached "statistical" cure. Parametric mixture cure model analysis on grouped relative survival curves provide an interesting way to determine the proportion of statistically cured cases and the mean survival time of the fatal cases in particular for ...

We propose a phase I clinical trial design that seeks to determine the cumulative safety of a series of administrations of a fixed dose of an investigational agent. In contrast with traditional phase I trials that are designed solely to find the maximum tolerated dose of the agent, our design instead identifies a maximum tolerated schedule that includes a maximum tolerated dose as well as a vec...

diagnosis of corneal diseases is possible by measuring and evaluation of corneal thickness in different layers. thus, the need for precise segmentation of corneal layer boundaries is inevitable. obviously, manual segmentation is time‑consuming and imprecise. in this paper, the gaussian mixture model (gmm) is used for automatic segmentation of three clinically important corneal boundaries on opt...

background : so far, several studies were conducted to estimate the prevalence of cigarette smoking in iran, but none of them used a statistical model to deal with unobserved smokers. the present study planned to estimate the accurate prevalence of cigarette smoking using mixture of truncated poisson distribution. methods : a cross-sectional study was conducted in hamadan, west of iran in 2009,...

background: the two most frequently diagnosed cancers among women worldwide are breast and cervical cancers. the objective of the present study was to classify the different countries based on the death rates from sex specific cancers. methods : in this cross-sectional study, we used dataset regarding death rate from breast, cervical, uterine, and ovarian cancers in 190 countries worldwide repo...

in a voice conversion system speech signal of a speaker (i.e. source speaker) is modified so that it sounds as if it had been pronounced by b speaker (i.e. target speaker). this process, sometimes, is called speaker conversion (changing speaker identity). achieved signal from speaker conversion system is desired to have high quality and very natural. to satisfy this, three major methods are pro...

BACKGROUND AND PURPOSE This study presents a statistical model to explore the presence of a population-based cure fraction in populations with a GBM. PATIENTS AND METHODS Data for this study was obtained from the Surveillance, Epidemiology and End-Results (SEER) database. Relative survival measures were modelled using non-mixture cure fraction models. RESULTS The extraction and subsequent p...