A new, two-dimensional overtone mobility spectrometry (OMS-OMS) instrument is described for the analysis of complex peptide mixtures. OMS separations are based on the differences in mobilities of ions in the gas phase. The method utilizes multiple drift regions with modulated drift fields such that only ions with appropriate mobilities are transmitted to the detector. Here we describe a hybrid ...

The available data on binary interactions are yet to be considered within the context of mixture risk assessment because of our inability to predict the effect of a third or a fourth chemical in the mixture on the interacting binary pairs. Physiologically based pharmacokinetic (PBPK) models represent a potentially useful framework for predicting the consequences of interactions in mixtures of i...

Mass spectrometry is the main analytical technique currently used to address the challenges of glycomics as it offers unrivalled levels of sensitivity and the ability to handle complex mixtures of different glycan variations. Determination of glycan structures from analysis of MS data is a major bottleneck in high-throughput glycomics projects, and robust solutions to this problem are of critic...

even purified enzyme preparations are often heterogeneous. for example, preparations of aspartate aminotransferase or cytochrome oxidase can consist of several different forms of the enzyme.  for this reason we consider how different the kinetics of the reactions catalysed by a mixture of forms of an enzyme must be to provide some indication of the characteristics of the species present.  based...

Cold-in-place recycling (CIR) is an environmentally sustainable alternative for preservation of asphalt pavements. A major disadvantage of this practice is the lower strength of the cold-in-place mixtures. Addition of cement into this type of mixture is a method for increasing its bearing capacity. The effect of cement content on the mechanical properties of the cold-in-place recycled asphalt m...

a second virial coefficient correlation suitable for two different temperatures ranges, (t*)-2£180 and (t*)-2>180, where t* is rt/dhvap is presented. the equation of state can be calculated for different, complicated non-polar, and slightly polar liquid mixtures at any temperature over the range from ttp to tc and up to high pressures. the latent heat of vaporization and density at the triple p...

By proposing a predictive method with no adjustable parameter and by using infinite dilution activity coefficients of components in binary mixtures obtained from UNIFAC model, the binary interaction parameters (k12) in van der Waals mixing rule (vdWMR) and Orbey-Sandler mixing rule (OSMR) have been evaluated. The predicted binary interaction parameters are used in Peng-Robinson-S...

Discrete mixtures of normal distributions are widely used in modeling amplitude fluctuations of electrical potentials at synapses of human and other animal nervous systems. The usual framework has independent data values yj arising as yj = mu j + xn0 + j, where the means mu j come from some discrete prior G(mu) and the unknown xno + j's and observed xj, j = 1,...,n0, are Gaussian noise terms. A...

The use of a finite mixture of normal distributions in model-based clustering allows us to capture non-Gaussian data clusters. However, identifying the clusters from the normal components is challenging and in general either achieved by imposing constraints on the model or by using post-processing procedures. Within the Bayesian framework, we propose a different approach based on sparse finite ...

The present experimental research investigates the feasibility of partial substitution of styrene-butadiene-styrene (SBS) with ground granulated blast-furnace slag (GGBS) for the modification of bitumen and porous asphalt mixtures. The control asphalt mixture and the seven modified porous asphalt mixtures have been analyzed separately and their performance was compared. Modified bitumen and asp...