نتایج جستجو برای: mmps activity

تعداد نتایج: 1137292  

Journal: :American journal of physiology. Regulatory, integrative and comparative physiology 2006
Vera Portik-Dobos Alex K Harris Weiwei Song Jimmie Hutchinson Maribeth H Johnson John D Imig David M Pollock Adviye Ergul

Although past studies have demonstrated decreased renal matrix metalloproteinase (MMP) activity in type 1 diabetes and in mesangial cells grown under high glucose conditions, renal MMP expression and activity in type 2 diabetes and the regulation of MMPs by profibrotic factors involved in diabetic renal complications such as endothelin-1 (ET-1) remained unknown. The renal expression and activit...

2016
Hala S. Alameddine Jennifer E. Morgan

In skeletal muscles, levels and activity of Matrix MetalloProteinases (MMPs) and Tissue Inhibitors of MetalloProteinases (TIMPs) have been involved in myoblast migration, fusion and various physiological and pathological remodeling situations including neuromuscular diseases. This has opened perspectives for the use of MMPs' overexpression to improve the efficiency of cell therapy in muscular d...

Journal: :Cardiovascular research 2006
Stefan Janssens H Roger Lijnen

Matrix metalloproteinases (MMPs) are a family of proteolytic enzymes responsible for extracellular protein degradation in the cardiovascular system. Originally known to play pivotal roles in tissue morphogenesis and wound healing, they have been shown to participate in the complex remodeling processes in blood vessels and the myocardium. The biological activity of MMPs is regulated at different...

2012
Derek L Mattey Jonathan C Packham Nicola B Nixon Lucy Coates Paul Creamer Sarah Hailwood Gordon J Taylor Ashok K Bhalla

INTRODUCTION The pathology of ankylosing spondylitis (AS) suggests that certain cytokines and matrix metalloproteinases (MMPs) might provide useful markers of disease activity. Serum levels of some cytokines and MMPs have been found to be elevated in active disease, but there is a general lack of information about biomarker profiles in AS and how these are related to disease activity and functi...

2015
Shane O'Sullivan John F Gilmer Carlos Medina

Matrix metalloproteinases (MMPs) are known to be upregulated in inflammatory bowel disease (IBD) and other inflammatory conditions, but while their involvement is clear, their role in many settings has yet to be determined. Studies of the involvement of MMPs in IBD since 2006 have revealed an array of immune and stromal cells which release the proteases in response to inflammatory cytokines and...

2006
MICHAEL STEFANIDAKIS Erkki Koivunen Carl G. Gahmberg Jari Ylänne Jukka Westermarck Antti Vaheri

REVIEW OF THE LITERATURE LEUKOCYTE ADHESION AND MIGRATION THE LEUKOCYTE MIGRATION CASCADE NEUTROPHIL FUNCTION AND ADHESION DURING INFLAMMATION Granulopoiesis and subsets of neutrophil granules INTEGRINS AND THEIR LIGANDS Structure and function of leukocyte β2 integrins Activation of leukocyte β2 integrins MATRIX METALLOPROTEINASES CLASSIFICATION OF MMPs STRUCTURAL FEATURES OF MMPs REGULATION OF...

2015
G. Daniel Grass Bryan P. Toole

Matrix metalloproteinases (MMPs) comprise a family of 23 zinc-dependent enzymes involved in various pathologic and physiologic processes. In cancer, MMPs contribute to processes from tumour initiation to establishment of distant metastases. Complex signalling and protein transport networks regulate MMP synthesis, cell surface presentation and release. Earlier attempts to disrupt MMP activity in...

Journal: :Annals of the rheumatic diseases 2000
Y Yoshihara H Nakamura K Obata H Yamada T Hayakawa K Fujikawa Y Okada

OBJECTIVE Matrix metalloproteinases (MMPs) are expressed in joint tissues of patients with rheumatoid arthritis (RA) and osteoarthritis (OA). The objective of this study was to define the steady state levels of seven different MMPs and two tissue inhibitors of metalloproteinases (TIMPs) as well as the potential metalloproteinase activity in the synovial fluid (SF) to provide more insight into t...

Journal: :Biomaterials 2004
Patrice Laquerriere Alexia Grandjean-Laquerriere Salima Addadi-Rebbah Edouard Jallot Dominique Laurent-Maquin Patrick Frayssinet Moncef Guenounou

After calcium-phosphates biomaterials based implantation like hydroxyapatite (HA) coating, particles are released in the periprosthetic tissues. Wear-debris induced fibrous membranes contain macrophage subsets that can produce metalloproteinases (MMPs), which are considered to be key enzymes in extra-cellular matrix turnover. Tissue inhibitors of metalloproteinases (TIMPs) are important regulat...

2014
Shane O’Sullivan John F. Gilmer Carlos Medina

Matrix metalloproteinases (MMPs) are known to be upregulated in inflammatory bowel disease (IBD) and other inflammatory conditions, but while their involvement is clear, their role in many settings has yet to be determined. Studies of the involvement of MMPs in IBD since 2006 have revealed an array of immune and stromal cells which release the proteases in response to inflammatory cytokines and...

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