Substitution of oxygen atoms by sulfur at various locations in the nucleic acid framework has led to analogs such as the DNA phosphorothioates and 4'-thio RNA. The phosphorothioates are excellent mimics of DNA, exhibit increased resistance to nuclease degradation compared with the natural counterpart, and have been widely used as first-generation antisense nucleic acid analogs for applications ...

We describe multiscale mortar mixed finite element discretizations for second order elliptic and nonlinear parabolic equations modeling Darcy flow in porous media. The continuity of flux is imposed via a mortar finite element space on a coarse grid scale, while the equations in the coarse elements (or subdomains) are discretized on a fine grid scale. We discuss the construction of multiscale mo...

Since the introduction of the mortar method as a coupling technique between the spectral and nite element methods see e g it has become the most important technique in domain decomposition methods for non matching grids The active research by the scienti c computation community in this eld is motivated by its exibility and great potential for large scale parallel compu tation see e g A good des...