Two types of Usher syndrome, a blindness-deafness disorder, result from mutations in the myosin VIIa gene. As for most other unconventional myosins, little is known about the function or functions of myosin VIIa. Here, we studied the photoreceptor cells of mice with mutant myosin VIIa by electron immunomicroscopy and microscopic autoradiography. We found evidence that myosin VIIa functions in t...

We have proposed that microtubules (MTs) destined for axons and dendrites are nucleated at the centrosome within the cell body of the neuron, and are then released for translocation into these neurites (Baas, P. W., and H. C. Joshi. 1992. J. Cell Biol. 119:171-178). In the present study, we have tested the capacity of the neuronal centrosome to act as a generator of MTs for relocation into othe...

BACKGROUND X-linked dystonia-deafness syndrome (DDS) is characterized by early-onset deafness followed by progressive dystonia in adulthood. Only 4 families with the syndrome have been reported, and all were white. OBJECTIVE To describe the first nonwhite family with X-linked DDS, involving 5 affected males in 4 generations. RESULTS Clinical features of the family members, who were Japanese...

Recenzja książki Karola Piotra Kulpy, Tyconius’ Theological Reception of 2 Thessalonians 2:3-12, seria History Biblical Exegesis 4, Mohr Siebeck, Tübingen 2022, ss. XIX + 319.

The non-linear mechanical characteristics of tailings under high pressure are the research foundation large-scale dams. Considering stress caused by tailing ponds, consolidated drained triaxial shear tests were carried out. deterioration mechanism mechanics was revealed particle crushing. test results show that sample density has a great influence on volumetric strain low pressure. However, is ...

Without a foundation of effective relationships, efforts to manage the flow of materials and information across the supply chain are likely to be unsuccessful (Supply Chain Challenges 2003; Handfield and Nichols 2002). Partnering between firms is one way to find and maintain competitive advantage (Mentzer, Min, and Zacharia 2000; Mohr and Spekman 1994). The ability to effectively and efficientl...